Panhypophysitis
Synonyms: Infundibulo-panhypophysitis
- Type
- Disease
- Group
- Disorder
- Age of onset
- Adolescent, Adult, Childhood, Elderly
- Status
- active
A type of primary hypophysitis characterized by an inflammation of the entire pituitary gland. Common clinical presentation is diabetes insipidus with polyuria and polydipsia and partial or panhypopituitarism. Other symptoms may include headaches, nausea/vomiting, visual disturbances and fatigue.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Panhypophysitis | Infundibulo-panhypophysitis |
| fr | Panhypophysite | Panhypophysite infundibulaire |
| de | Hypophysitis, nekrotisierende | Infundibulohypophysitis, nekrotisierende |
| es | Panhipofisitis | Panhipofisitis-infundibulo |
| it | Panipofisite | Panipofisite infundibolare |
| nl | Panhypofysitis | Infundibulo-panhypofysitis |
| pt | Hipofisite necrotizante | |
| pl | Zapalenie przysadki | = en |
| cs | Panhypofyzitida | Infundibulo-panhypofyzitida |
| uk | Пангіпофізит | Інфундибуло-пангіпофізит |
| zh | 全垂体炎 | 漏斗-全垂体炎 |
| tr | Panhipofizit | İnfundibulo-panhipofizit |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | E23.6 | NTBT | attributed | validated |
| ICD-11 | 5A61.0 | NTBT | attributed | validated |
| MONDO | 0019839 | E | validated | |
| UMLS | C5190786 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:95506Primary hypophysitis
rare endocrine diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
0 recordsNo prevalence record in this release.
HPO phenotypes
35 annotations · validated 2017-06-28| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0011751 | Abnormality of the posterior pituitary | |
| HP:0000863 | Central diabetes insipidus | |
| HP:0000871 | Panhypopituitarism | |
| Frequent (79-30%) | ||
| HP:0012504 | Abnormal size of pituitary gland | |
| HP:0012696 | Abnormal thalamic MRI signal intensity | |
| HP:0011748 | Adrenocorticotropic hormone deficiency | |
| HP:0011735 | Adrenocorticotropin deficient adrenal insufficiency | |
| HP:0000141 | Amenorrhea | |
| HP:0000622 | Blurred vision | |
| HP:0008163 | Decreased circulating cortisol level | |
| HP:0030018 | Decreased female libido | |
| HP:0040306 | Decreased male libido | |
| HP:0008214 | Decreased serum estradiol | |
| HP:0040171 | Decreased serum testosterone concentration | |
| HP:0008213 | Gonadotropin deficiency | |
| HP:0002315 | Headache | |
| HP:0003158 | Hyposthenuria | |
| HP:0000802 | Impotence | |
| HP:0000870 | Increased circulating prolactin concentration | |
| HP:0002018 | Nausea | |
| HP:0001895 | Normochromic anemia | |
| HP:0001278 | Orthostatic hypotension | |
| HP:0000980 | Pallor | |
| HP:0008245 | Pituitary hypothyroidism | |
| HP:0001959 | Polydipsia | |
| HP:0007987 | Progressive visual field defects | |
| HP:0008240 | Secondary growth hormone deficiency | |
| Occasional (29-5%) | ||
| HP:0003493 | Antinuclear antibody positivity | |
| HP:0007041 | Chronic lymphocytic meningitis | |
| HP:0000651 | Diplopia | |
| HP:0000872 | Hashimoto thyroiditis | |
| HP:0002902 | Hyponatremia | |
| HP:0004396 | Poor appetite | |
| HP:0008202 | Reduced circulating prolactin concentration | |
| HP:0000407 | Sensorineural hearing impairment | |
Run the differential on the 3 obligate / very frequent terms
Annotation source: 23885185[PMID]_27008424[PMID]_18987830[PMID]_17273922[PMID]_14606714[PMID]_27165294[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/95513
- This record as JSON: /data/d/95513.json