ORPHA:91139
Simple cryoglobulinemia
Synonyms: Cryoglobulinemia type 1
- Type
- Disease
- Group
- Disorder
- Age of onset
- Adult, Elderly
- Status
- active
Simple (monoclonal) cryoglobulinemia or type I cryoglobulinemia refers to the presence in the serum of one isotype or subclass of immunoglobulin (Ig) that precipitates reversibly below 37°C.
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Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Simple cryoglobulinemia | Cryoglobulinemia type 1 |
| fr | Cryoglobulinémie simple | Cryoglobulinémie type I |
| de | Kryoglobulinämie, einfache | Kryoglobulinämie Typ I |
| es | Crioglobulinemia simple | Crioglobulinemia tipo 1 · Crioglobulinemia tipo I |
| it | Crioglobulinemia semplice | Crioglobulinemia, tipo 1 |
| nl | Eenvoudige cryoglobulinemie | Cryoglobulinemie type 1 |
| pt | Crioglobulinemia simples | |
| pl | Krioglobulinemia prosta | Krioglobulinemia typu 1 |
| cs | Monoklonální kryoglobulinémie | Kryoglobulinémie, typ 1 |
| uk | Проста кріоглобулінемія | Кріоглобулінемія типу 1 |
| zh | 单克隆冷球蛋白血症 | 冷球蛋白血症1型 |
| tr | Basit kriyoglobulinemi | Kriyoglobulinemi tip 1 |
Definition in:
2
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | D89.1 | NTBT | attributed | validated |
| ICD-11 | 4B22 | NTBT | index | validated |
| MONDO | 0019606 | E | validated | |
| UMLS | C4510006 | E | validated | |
| GARD | 6217 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
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Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:97992Rare hematologic disease
rare hematological diseases
No children.
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Genes
0 directOrphanet records no gene directly on this code.
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Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only | Not yet validated | ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
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HPO phenotypes
55 annotations · validated 2021-10-13| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0001871 | Abnormality of blood and blood-forming tissues | |
| HP:0410135 | Cold urticaria | |
| HP:0000979 | Purpura | |
| Frequent (79-30%) | ||
| HP:0006121 | Acral ulceration | |
| HP:0007067 | Distal peripheral sensory neuropathy | |
| HP:0012378 | Fatigue | |
| HP:0003496 | Increased circulating IgM level | |
| HP:0033260 | Livedo racemosa | |
| HP:0011355 | Localized skin lesion | |
| HP:0032018 | Multiple mononeuropathy | |
| HP:0031047 | Paraproteinemia | |
| HP:0009830 | Peripheral neuropathy | |
| HP:0030880 | Raynaud phenomenon | |
| HP:0007141 | Sensorimotor neuropathy | |
| HP:0001955 | Unexplained fevers | |
| Occasional (29-5%) | ||
| HP:0000077 | Abnormality of the kidney | |
| HP:0002829 | Arthralgia | |
| HP:0001369 | Arthritis | |
| HP:0012191 | B-cell lymphoma | |
| HP:0000822 | Hypertension | |
| HP:0000793 | Membranoproliferative glomerulonephritis | |
| HP:0012574 | Mesangial hypercellularity | |
| HP:0002907 | Microscopic hematuria | |
| HP:0032290 | Monoclonal elevation of IgG | |
| HP:0005508 | Monoclonal immunoglobulin M proteinemia | |
| HP:0006775 | Multiple myeloma | |
| HP:0003401 | Paresthesia | |
| HP:0000093 | Proteinuria | |
| HP:0000083 | Renal insufficiency | |
| HP:0010833 | Spontaneous pain sensation | |
| HP:0011276 | Vascular skin abnormality | |
| HP:0002633 | Vasculitis | |
| HP:0001824 | Weight loss | |
| Very rare (<4-1%) | ||
| HP:0002027 | Abdominal pain | |
| HP:0001627 | Abnormal heart morphology | |
| HP:0002088 | Abnormal lung morphology | |
| HP:0011024 | Abnormality of the gastrointestinal tract | |
| HP:0005550 | Chronic lymphatic leukemia | |
| HP:0004431 | Complement deficiency | |
| HP:0001635 | Congestive heart failure | |
| HP:0006824 | Cranial nerve paralysis | |
| HP:0004302 | Functional motor deficit | |
| HP:0002239 | Gastrointestinal hemorrhage | |
| HP:0002315 | Headache | |
| HP:0032335 | Monoclonal elevation of circulating IgA | |
| HP:0002011 | Morphological central nervous system abnormality | |
| HP:0001658 | Myocardial infarction | |
| HP:0000123 | Nephritis | |
| HP:0000100 | Nephrotic syndrome | |
| HP:0001701 | Pericarditis | |
| HP:0002344 | Progressive neurologic deterioration | |
| HP:0002923 | Rheumatoid factor positive | |
| HP:0001250 | Seizure | |
| HP:0001297 | Stroke | |
| HP:0006562 | Viral hepatitis | |
Run the differential on the 3 obligate / very frequent terms
Annotation source: 31355088[PMID]_32535708[PMID]_30731128[PMID]
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Sources for this card
- Orphanet page: orpha.net/en/disease/detail/91139
- This record as JSON: /data/d/91139.json