Systemic monochloroacetate poisoning
- Type
- Disease
- Group
- Disorder
- Age of onset
- All ages
- Status
- active
Systemic monochloroacetate poisoning is a rare, life-threatening intoxication with monochloroacetic acid (mainly through the skin, but also by inhalation or ingestion). It is characterized by vomiting, diarrhea and central nervous system (CNS)-excitability (disorientation, delirium, convulsions) as early signs of systemic poisoning, followed by CNS-depression, coma and cerebral edema. Additional signs include heart involvement (severe myocardial depression, shock, arrhythmias, nonspecific myocardial damage), severe metabolic acidosis, hypokalemia, hypocalcemia and progressive renal failure leading to anuria. Myoglobinemia and leukocytosis may occur. Manifestations may be delayed for 1-4 hours.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Systemic monochloroacetate poisoning | |
| fr | Intoxication systémique au monochloroacétate | |
| de | Monochloracetat-Vergiftung, systemische | |
| es | Intoxicación sistémica por monocloroacetato | |
| it | Avvelenamento sistemico da monocloroacetato | |
| nl | Systemische monochloroacetaatvergiftiging | |
| pt | Envenenamento sistémico por monocloroacetato | |
| pl | Ogólne zatrucie kwasem monochlorooctowym | |
| cs | Systémová otrava monochlóracetátem | |
| uk | Системне отруєння монохлорацетатом | |
| zh | 全身性氯乙酸中毒 | |
| tr | Sistemik monokloroasetat zehirlenmesi |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | T60.3 | NTBT | index | validated |
| ICD-11 | NE61 | NTBT | attributed | validated |
| MONDO | 0019545 | E | validated | |
| UMLS | C4707283 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:556508Rare disorder due to poisoning
rare disorders due to toxic effects
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | <1 / 1 000 000 | — | Europe | Class only | Validated | European Medicines Agency 2004[OTHER] |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
Orphanet has no HPO annotation for this code in this release.
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/90069
- This record as JSON: /data/d/90069.json