Acute peripheral arterial occlusion
- Type
- Particular clinical situation in a disease or syndrome
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- All ages
- Status
- active
A rare vascular condition characterized by the sudden blockage of an artery supplying blood to the limbs by a blood clot, causing acute limb ischemia. The clinical presentation is variable and depends on the time course of vessel occlusion, the presence of an underlying vascular disease, and the recruitment of collateral circulation. Symptoms can develop over a period of hours to days and typically include limb pain, pallor, absent pulse, poikilothermia, paresthesia, and limb paralysis. The condition can quickly progress to infarction and loss of the limb.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Acute peripheral arterial occlusion | |
| fr | Occlusion artérielle périphérique aiguë | |
| de | Akuter peripherer Arterienverschluss | |
| es | Oclusión arterial periférica aguda | |
| it | Occlusione arteriosa periferica acuta | |
| nl | Acute perifere arteriële occlusie | |
| pt | Oclusão arterial periférica aguda | |
| pl | Ostra obwodowa okluzja tętnicy | |
| cs | Akutní periferní arteriální okluze | Akutní periferní uzávěr arterie |
| uk | Гостра оклюзія периферичних артерій | |
| zh | 急性外周动脉闭塞 | |
| tr | Akut periferik arter tıkanıklığı |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | I74.4 | NTBT | attributed | validated |
| ICD-11 | BD30 | NTBT | attributed | validated |
| UMLS | C5681343 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:496924Non-inflammatory vasculopathy
rare circulatory system diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | 1-5 / 10 000 | 16 / 100 000 | Europe | Value and class | Validated | European Medicines Agency[OTHER] |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
17 annotations · validated 2020-03-13| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0025018 | Abnormal capillary physiology | |
| HP:0011121 | Abnormal skin morphology | |
| HP:0009763 | Limb pain | |
| HP:0012514 | Lower limb pain | |
| HP:0000980 | Pallor | |
| Frequent (79-30%) | ||
| HP:0030846 | Abnormality of venous physiology | |
| HP:0031271 | Absent ankle pulse | |
| HP:0006937 | Impaired distal tactile sensation | |
| HP:0001974 | Increased total leukocyte count | |
| HP:0003690 | Limb muscle weakness | |
| HP:0003401 | Paresthesia | |
| Occasional (29-5%) | ||
| HP:0001941 | Acidosis | |
| HP:0100758 | Gangrene | |
| HP:0001658 | Myocardial infarction | |
| HP:0003470 | Paralysis | |
| HP:0001297 | Stroke | |
| HP:0004755 | Supraventricular tachycardia | |
Run the differential on the 5 obligate / very frequent terms
Annotation source: 4593615[PMID]_26375664[PMID]_28722881[PMID]_28987435[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/90064
- This record as JSON: /data/d/90064.json