Sepsis in premature infants
- Type
- Particular clinical situation in a disease or syndrome
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- Neonatal
- Status
- active
A rare systemic condition affecting neonates born at less than 37 weeks gestational age and characterized by life-threatening organ dysfunction caused by a dysregulated host response to an infection, which may have been acquired shortly before or during birth (resulting in early-onset neonatal sepsis during the first 72 hours of life), or after birth (leading to late-onset neonatal sepsis between 72 hours and three months). Prematurity constitutes one of the primary risk factors for neonatal sepsis. The clinical picture may develop gradually with signs and symptoms like irritability, lethargy, or poor feeding, or progress rapidly to respiratory distress, fever, hypothermia, hypotension, shock, and multiple organ failure.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Sepsis in premature infants | |
| fr | Sepsis chez le nouveau-né prématuré | |
| de | Sepsis bei Frühgeborenen | |
| es | Sepsis en neonatos prematuros | |
| it | Sepsi nei neonati prematuri | |
| nl | Sepsis bij premature zuigeling | |
| pt | Sépsis de apresentação tardia em lactentes prematuros | |
| pl | Sepsa u wcześniaków | |
| cs | Sepse u nedonošených | |
| uk | Сепсис у недоношених дітей | |
| zh | 早产儿败血症 | |
| tr | Prematüre bebeklerde sepsis |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | P36.0 | NTBT | attributed | validated |
| ICD-10 | P36.1 | NTBT | attributed | validated |
| ICD-10 | P36.2 | NTBT | attributed | validated |
| ICD-10 | P36.3 | NTBT | attributed | validated |
| ICD-10 | P36.4 | NTBT | attributed | validated |
| ICD-10 | P36.5 | NTBT | attributed | validated |
| ICD-10 | P36.8 | NTBT | attributed | validated |
| ICD-10 | P36.9 | NTBT | attributed | validated |
| ICD-11 | KA60 | NTBT | attributed | validated |
| UMLS | C5681350 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:182222Rare systemic disease
rare systemic and rheumatological diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | 1-5 / 10 000 | 32 / 100 000 | Europe | Value and class | Validated | European Medicines Agency[OTHER] |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
51 annotations · validated 2020-02-14| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0010978 | Abnormality of immune system physiology | |
| HP:0040187 | Neonatal sepsis | |
| HP:0001622 | Premature birth | |
| HP:0001518 | Small for gestational age | |
| HP:0001649 | Tachycardia | |
| Frequent (79-30%) | ||
| HP:0003270 | Abdominal distention | |
| HP:0031602 | Abnormal mucociliary clearance | |
| HP:0011410 | Caesarian section | |
| HP:0004325 | Decreased body weight | |
| HP:0001875 | Decreased total neutrophil count | |
| HP:0002094 | Dyspnea | |
| HP:0011227 | Elevated circulating C-reactive protein concentration | |
| HP:0001945 | Fever | |
| HP:0012719 | Functional abnormality of the gastrointestinal tract | |
| HP:0002579 | Gastrointestinal dysmotility | |
| HP:0002045 | Hypothermia | |
| HP:0030783 | Increased circulating interleukin 6 concentration | |
| HP:0001974 | Increased total leukocyte count | |
| HP:0001942 | Metabolic acidosis | |
| HP:0001319 | Neonatal hypotonia | |
| HP:0000980 | Pallor | |
| HP:0032169 | Severe infection | |
| Occasional (29-5%) | ||
| HP:0001892 | Abnormal bleeding | |
| HP:0002795 | Abnormal respiratory system physiology | |
| HP:0000236 | Abnormality of the anterior fontanelle | |
| HP:0001903 | Anemia | |
| HP:0001662 | Bradycardia | |
| HP:0000961 | Cyanosis | |
| HP:0001410 | Decreased liver function | |
| HP:0002014 | Diarrhea | |
| HP:0000969 | Edema | |
| HP:0004387 | Enterocolitis | |
| HP:0002240 | Hepatomegaly | |
| HP:0001265 | Hyporeflexia | |
| HP:0002615 | Hypotension | |
| HP:0000952 | Jaundice | |
| HP:0001287 | Meningitis | |
| HP:0030863 | Nasal flaring | |
| HP:0100520 | Oliguria | |
| HP:0000967 | Petechiae | |
| HP:0002686 | Prenatal maternal abnormality | |
| HP:0000979 | Purpura | |
| HP:0004713 | Reversible renal failure | |
| HP:0001250 | Seizure | |
| HP:0001744 | Splenomegaly | |
| HP:0005968 | Temperature instability | |
| HP:0001873 | Thrombocytopenia | |
| HP:0002013 | Vomiting | |
| Very rare (<4-1%) | ||
| HP:0011880 | Acute disseminated intravascular coagulation | |
| HP:0031696 | Disseminated viral infection | |
| HP:0020101 | Invasive fungal infection | |
Run the differential on the 5 obligate / very frequent terms
Annotation source: 28709162[PMID]_27589549[PMID]_30207217[PMID]_28434651[PMID]_29382648[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/90051
- This record as JSON: /data/d/90051.json