raremaprare-disease reference indexOrphadata 2026-06-23 · HPO 2026-09-01
ORPHA:88673

Hepatocellular carcinoma

Synonyms: HCC

Type
Clinical group
Group
Group of disorders
Inheritance
Not applicable
Age of onset
All ages
Status
active

Hepatocellular carcinoma is a primary hepatic cancer derived from well-differentiated hepatocytes. It is more frequent in adults than in childhood. Symptoms are hepatic mass, abdominal pain and, in advanced stages, jaundice, cachexia and liver failure.

1

Names in Orphadata languages

12 of 12 languages
LangNameSynonyms
enHepatocellular carcinomaHCC
frCarcinome hépatocellulaireCHC · HCC
deHepatozelluläres KarzinomHCC · Leberzellkarzinom
esCarcinoma hepatocelular= en
itCarcinoma epatocellulare= en
nlHepatocellulair carcinoom= en
ptCarcinoma hepatocelular= en
plRak wątrobowokomórkowy= en
csHepatocelulární karcinom= en
ukГепатоцелюлярна карцинома= en
zh肝细胞癌= en
trHepatosellüler karsinom= en

Definition in:

2

Cross-references

qualifier = Orphanet mapping relation
SourceCodeQualifierICD relationValidation
OMIM114550Evalidated
ICD-10C22.0Especificvalidated
ICD-112C12.02Especificvalidated
MONDO0007256Evalidated
MONDO7256Evalidated
MeSHD006528Evalidated
UMLSC2239176Evalidated
MedDRA10049010Evalidated

E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.

3

Classification

Preferential parent (Orphanet linearisation):

Parents in the classifications (2):

Children (2):

4

Genes

0 direct

Orphanet records no gene directly on this code.

5

Prevalence and incidence

34 records
TypeClassValueAreaQualificationValidationSource
Annual incidence1-9 / 100 0006.2 / 100 000United StatesValue and classValidated25142309[PMID]_SEER Surveillance Epidemiology and End Results 1973-2011[OTHER]
Point prevalence1-5 / 10 00015 / 100 000EuropeValue and classValidatedEuropean Medicines Agency 2017[OTHER]
Annual incidence1-9 / 100 0006.264 / 100 000FranceValue and classValidatedRARECARE surveillance of rare cancers in Europe[OTHER]
Annual incidence1-9 / 100 0002.106 / 100 000United KingdomValue and classValidatedRARECARE surveillance of rare cancers in Europe[OTHER]
Annual incidence1-9 / 100 0005.129 / 100 000GermanyValue and classValidatedRARECARE surveillance of rare cancers in Europe[OTHER]
Annual incidence1-9 / 100 0005.212 / 100 000SpainValue and classValidatedRARECARE surveillance of rare cancers in Europe[OTHER]
Annual incidence1-9 / 100 0009.266 / 100 000ItalyValue and classValidatedRARECARE surveillance of rare cancers in Europe[OTHER]
Annual incidence1-5 / 10 00015 / 100 000GreeceValue and classValidated22537432[PMID]
Annual incidence1-9 / 100 0005 / 100 000CanadaValue and classValidated22537432[PMID]
Annual incidence1-9 / 100 0005 / 100 000OceaniaValue and classValidated22537432[PMID]
Annual incidence1-5 / 10 00012.5 / 100 000Latin AmericaValue and classValidated22537432[PMID]_18666317[PMID]_ ORPHANET
Annual incidence1-5 / 10 00035 / 100 000ChinaValue and classValidated12095924[PMID]
Annual incidence1-5 / 10 00029 / 100 000JapanValue and classValidated12095924[PMID]
Annual incidence1-5 / 10 00049 / 100 000Korea, Republic ofValue and classValidated12095924[PMID]
Annual incidence6-9 / 10 00099 / 100 000MongoliaValue and classValidated12095924[PMID]
Annual incidence1-5 / 10 00016 / 100 000AfricaValue and classValidated18666317[PMID]_20616577[PMID]_22537432[PMID]
Annual incidence1-9 / 100 0003.221 / 100 000EuropeValue and classValidatedRARECARE surveillance of rare cancers in Europe[OTHER]
Annual incidence1-9 / 100 0005.296 / 100 000AustriaValue and classValidatedRARECARE surveillance of rare cancers in Europe[OTHER]
Annual incidence1-9 / 100 0002.275 / 100 000BelgiumValue and classValidatedRARECARE surveillance of rare cancers in Europe[OTHER]
Annual incidence1-9 / 100 0001.697 / 100 000BulgariaValue and classValidatedRARECARE surveillance of rare cancers in Europe[OTHER]
Annual incidence1-9 / 100 0002.762 / 100 000CroatiaValue and classValidatedRARECARE surveillance of rare cancers in Europe[OTHER]
Annual incidence1-9 / 100 0002.979 / 100 000Czech RepublicValue and classValidatedRARECARE surveillance of rare cancers in Europe[OTHER]
Annual incidence1-9 / 100 0001.487 / 100 000EstoniaValue and classValidatedRARECARE surveillance of rare cancers in Europe[OTHER]
Annual incidence1-9 / 100 0003.382 / 100 000FinlandValue and classValidatedRARECARE surveillance of rare cancers in Europe[OTHER]
Annual incidence1-9 / 100 0001.278 / 100 000IcelandValue and classValidatedRARECARE surveillance of rare cancers in Europe[OTHER]
Annual incidence1-9 / 100 0001.045 / 100 000IrelandValue and classValidatedRARECARE surveillance of rare cancers in Europe[OTHER]
Annual incidence1-9 / 100 0001.933 / 100 000LatviaValue and classValidatedRARECARE surveillance of rare cancers in Europe[OTHER]
Annual incidence1-9 / 100 0001.146 / 100 000LithuaniaValue and classValidatedRARECARE surveillance of rare cancers in Europe[OTHER]
Annual incidence1-9 / 100 0001.627 / 100 000NorwayValue and classValidatedRARECARE surveillance of rare cancers in Europe[OTHER]
Annual incidence1-9 / 1 000 0000.925 / 100 000PolandValue and classValidatedRARECARE surveillance of rare cancers in Europe[OTHER]
Annual incidence1-9 / 100 0002.345 / 100 000PortugalValue and classValidatedRARECARE surveillance of rare cancers in Europe[OTHER]
Annual incidence1-9 / 100 0002.762 / 100 000SlovakiaValue and classValidatedRARECARE surveillance of rare cancers in Europe[OTHER]
Annual incidence1-9 / 100 0006.649 / 100 000SwitzerlandValue and classValidatedRARECARE surveillance of rare cancers in Europe[OTHER]
Annual incidence1-9 / 100 0001.127 / 100 000NetherlandsValue and classValidatedRARECARE surveillance of rare cancers in Europe[OTHER]

Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.

6

HPO phenotypes

Orphanet has no HPO annotation for this code in this release.

7

Sources for this card