Complex regional pain syndrome
Synonyms: Sudeck's atrophy · Causalgia · Reflex sympathetic dystrophy · Algodystrophy · Algoneurodystrophy
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- All ages
- Status
- active
A rare neurologic disease characterized by persistent pain that is disproportionate to the inciting event. The pain is regional, usually affecting a limb with a distal predominance, and may occur spontaneously or be stimulus-induced. It is associated with sensory disturbances, vasomotor abnormalities (including changes in skin color and temperature), sudomotor abnormalities, edema, and motor or trophic changes. Symptoms often develop following trauma, fractures, immobilization, surgery, or nerve injury, and their severity and clinical presentation can vary considerably among patients.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Complex regional pain syndrome | Sudeck's atrophy · Causalgia · Reflex sympathetic dystrophy · Algodystrophy · Algoneurodystrophy |
| fr | Syndrome douloureux régional complexe | Dystrophie sympathique réflexe · Algodystrophie · Algoneurodystrophie · Atrophie de Sudeck · Causalgie |
| de | Komplexes regionales Schmerzsyndrom | Kausalgie · Sudeck-Atrophie · CRPS |
| es | Síndrome de dolor regional complejo | Algoneurodistrofia · Atrofia de Sudeck · Causalgia · Distrofia simpática refleja · Algodistrofia |
| it | Sindrome da dolore regionale complesso | Causalgia · Distrofia simpatica riflessa · Algodistrofia · Atrofia di Sudeck · Algoneurodistrofia |
| nl | Complex regionaal pijnsyndroom | Atrofie van Sudeck · Sudeck-atrofie · Causalgie · Sympathische reflexdystrofie · Algodystrofie · Algoneurodystrofie · CRPS |
| pt | Síndrome dor regional complexa | |
| pl | Zespół złożonego bólu miejscowego | = en |
| cs | Komplexní regionální bolestivý syndrom | KRBS · Sudeckův syndrom |
| uk | Комплексний регіональний больовий синдром | |
| zh | 复杂性局部疼痛综合征 | |
| tr | Kompleks bölgesel ağrı sendromu |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| OMIM | 604335 | BTNT | validated | |
| ICD-10 | G90.5 | BTNT | attributed | validated |
| ICD-10 | G90.6 | BTNT | attributed | validated |
| ICD-11 | MG30.04 | E | specific | validated |
| MONDO | 0019369 | E | validated | |
| MeSH | D020918 | E | validated | |
| UMLS | C0458219 | E | validated | |
| GARD | 4647 | E | validated | |
| MedDRA | 10064332 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:98006Rare neurologic disease
rare neurological diseases
No children.
Codes that Orphanet moved or referred to this one:
- ORPHA:99994OBSOLETE: Complex regional pain syndrome type 2 referred to · inactive
- ORPHA:99995OBSOLETE: Complex regional pain syndrome type 1 referred to · inactive
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
2 records| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Annual incidence | 1-5 / 10 000 | 26.2 / 100 000 | Netherlands | Value and class | Validated | 17084977[PMID]_24161450[PMID] |
| Point prevalence | Unknown | — | Worldwide | Class only | Validated | ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
12 annotations · validated 2018-09-17| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0009763 | Limb pain | |
| Frequent (79-30%) | ||
| HP:0040170 | Abnormality of hair growth | |
| HP:0012533 | Allodynia | |
| HP:0000958 | Dry skin | |
| HP:0012534 | Dysesthesia | |
| HP:0010742 | Edema of the upper limbs | |
| HP:0010783 | Erythema | |
| HP:0004305 | Involuntary movements | |
| HP:0010741 | Pedal edema | |
| HP:0008383 | Slow-growing nails | |
| HP:0003474 | Somatic sensory dysfunction | |
| HP:0010834 | Trophic changes related to pain | |
Run the differential on the 1 obligate / very frequent terms
Annotation source: 10522900[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/83452
- This record as JSON: /data/d/83452.json