Boutonneuse fever
Synonyms: Mediterranean spotted fever
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- All ages
- Status
- active
A rare spotted fever rickettsiosis caused by infection with the tick-borne bacterium <i>Rickettsia conorii</i>, characterized by the onset of fever after an incubation period of about a week, followed by a centripetally spreading maculopapular rash, which may evolve into a petechial form. Accompanying symptoms are headaches, myalgia and/or arthralgia, among others. The typical ''tache noire'' may be observed at the site of the tick bite for several days. The disease is endemic in Africa, Southern Europe, and India.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Boutonneuse fever | Mediterranean spotted fever |
| fr | Fièvre boutonneuse | Fièvre boutonneuse méditerranéenne |
| de | Boutonneuse-Fieber | Mittelmeer-Fleckfieber |
| es | Fiebre botonosa | Fiebre manchada mediterránea |
| it | Febbre bottonosa | |
| nl | Boutonneuse koorts | Fièvre boutonneuse · Mediterrane gevlekte koorts |
| pt | Febre de Boutonneuse | Febre de Marselha · Febre maculosa mediterrânica · Febre por mordedura da carraça queniana · Tifo da carraça africana · Tifo da carraça indiana · Tifo da carraça queniana |
| pl | Gorączka plamista Boutonneuse | Śródziemnomorska gorączka plamista · Śródziemnomorska gorączka plamista |
| cs | Marseillská horečka | Horečka boutonneuse · Exantematózní horečka |
| uk | Плямиста лихоманка | Середземноморська плямиста лихоманка |
| zh | 南欧斑疹热 | 地中海斑疹热 |
| tr | Boutonneuse ateşi | Akdeniz benekli ateşi |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | A77.1 | NTBT | inclusion | validated |
| ICD-11 | 1C31.1 | E | specific | validated |
| MONDO | 0024472 | E | validated | |
| MeSH | D001907 | E | validated | |
| UMLS | C0006060 | E | validated | |
| MedDRA | 10006045 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:102022Spotted fever rickettsiosis
rare infectious diseases
No children.
Codes that Orphanet moved or referred to this one:
- ORPHA:101335OBSOLETE: Indian tick typhus referred to · inactive
- ORPHA:101336OBSOLETE: Kenya tick typhus referred to · inactive
- ORPHA:101337OBSOLETE: Marseilles fever referred to · inactive
- ORPHA:101338OBSOLETE: Mediterranean spotted fever referred to · inactive
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
3 records| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | 1-5 / 10 000 | 24.2 / 100 000 | France | Value and class | Not yet validated | ORPHANET |
| Point prevalence | 1-9 / 100 000 | 9.8 / 100 000 | Portugal | Value and class | Not yet validated | ORPHANET |
| Point prevalence | 1-5 / 10 000 | — | Europe | Class only | Not yet validated | ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
26 annotations · validated 2020-04-22| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0100872 | Abnormality of the plantar skin of foot | |
| HP:0040211 | Abnormality of the skin of the palm | |
| HP:0001945 | Fever | |
| HP:0000988 | Skin rash | |
| Frequent (79-30%) | ||
| HP:0002829 | Arthralgia | |
| HP:0025289 | Cervical lymphadenopathy | |
| HP:0002910 | Elevated circulating hepatic transaminase concentration | |
| HP:0002315 | Headache | |
| HP:0003496 | Increased circulating IgM level | |
| HP:0002716 | Lymphadenopathy | |
| HP:0012733 | Macule | |
| HP:0040186 | Maculopapular exanthema | |
| HP:0003326 | Myalgia | |
| HP:0000083 | Renal insufficiency | |
| HP:0032156 | Skin detachment | |
| HP:0200036 | Skin nodule | |
| HP:0001873 | Thrombocytopenia | |
| Occasional (29-5%) | ||
| HP:0002027 | Abdominal pain | |
| HP:0002014 | Diarrhea | |
| HP:0003237 | Increased circulating IgG level | |
| HP:0001882 | Leukopenia | |
| HP:0002018 | Nausea | |
| HP:0000967 | Petechiae | |
| Very rare (<4-1%) | ||
| HP:0000613 | Photophobia | |
| HP:0002878 | Respiratory failure | |
| HP:0002633 | Vasculitis | |
Run the differential on the 4 obligate / very frequent terms
Annotation source: 27380385[PMID]_29855412[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/83313
- This record as JSON: /data/d/83313.json