raremaprare-disease reference indexOrphadata 2026-06-23 · HPO 2026-09-01
ORPHA:726004

Astrocytoma grade 4

Type
Disease
Group
Disorder
Inheritance
Not applicable
Age of onset
All ages
Status
active

Orphadata ships no English definition for this code.

1

Names in Orphadata languages

9 of 12 languages
LangNameSynonyms
enAstrocytoma grade 4
frAstrocytome de grade 4
deAstrozytom Grad 4
esAstrocitoma grado 4
itAstrocitoma di grado 4
nlAstrocytoom graad 4
ptAstrocytoma grade 4
plAstrocytoma grade 4
csAstrocytoma grade 4
2

Cross-references

qualifier = Orphanet mapping relation

No cross-references in this release.

3

Classification

Preferential parent (Orphanet linearisation):

Parents in the classifications (1):

No children.

4

Genes

4 direct
GeneAssociationStatusHGNCEnsemblOMIMLocusNameSource of validation
ATRXDisease-causing somatic mutation(s) inAssessedHGNC:886ENSG00000085224300032Xq21.1ATRX chromatin remodeler35047821[PMID]
IDH1Disease-causing somatic mutation(s) inAssessedHGNC:5382ENSG000001384131477002q34isocitrate dehydrogenase (NADP(+)) 137667984[PMID]_33177376[PMID]_31996992[PMID]
IDH2Disease-causing somatic mutation(s) inAssessedHGNC:5383ENSG0000018205414765015q26.1isocitrate dehydrogenase (NADP(+)) 233177376[PMID]
TP53Disease-causing somatic mutation(s) inAssessedHGNC:11998ENSG0000014151019117017p13.1tumor protein p5337667984[PMID]_33177376[PMID]_31996992[PMID]
5

Prevalence and incidence

1 record
TypeClassValueAreaQualificationValidationSource
Point prevalenceUnknown—WorldwideClass onlyValidatedORPHANET

Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.

6

HPO phenotypes

Orphanet has no HPO annotation for this code in this release.

7

Sources for this card