Pneumocystosis
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- All ages
- Status
- active
Human pneumocystosis is caused by an infectious agent, which (after recent nomenclature and taxonomy revisions) is now classed as the fungus <i>Pneumocystis jiroveci</i>. The prevalence is unknown. <i>Pneumocystis jiroveci</i> is an opportunistic infectious agent, developing in immunosuppressed patients. It is an air-borne infection, localised to the lungs. However, extrapulmonary involvement is seen in AIDS patients. The disease manifests progressively with coughing, respiratory problems (dyspnea) and fever, followed by acute respiratory insufficiency and death within a few weeks in untreated cases. The most reliable diagnostic method is bronchoalveolar lavage. The treatment of choice is cotrimoxazole.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Pneumocystosis | |
| fr | Pneumocystose | |
| de | Pneumozystose | |
| es | Neumocistosis | |
| it | Pneumocitosi | |
| nl | Pneumocystose | |
| pt | Pneumocistose | |
| pl | Pneumocystoza | |
| cs | Pneumocystóza | |
| uk | Пневмоцистоз | |
| zh | 肺孢子虫病 | |
| tr | Pnömositoz |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | B48.5+ | E | specific | validated |
| ICD-10 | J17.2* | NTBT | index | validated |
| ICD-11 | 1F2G | E | specific | validated |
| MONDO | 0019121 | E | validated | |
| MeSH | D011020 | E | validated | |
| UMLS | C5779637 | E | validated | |
| GARD | 4386 | E | validated | |
| MedDRA | 10035662 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:163591Rare mycosis
rare infectious diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only | Validated | ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
23 annotations · validated 2020-04-15| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0011949 | Acute infectious pneumonia | |
| HP:0002094 | Dyspnea | |
| HP:0001945 | Fever | |
| HP:0012418 | Hypoxemia | |
| HP:0020102 | Pneumocystis jirovecii pneumonia | |
| Frequent (79-30%) | ||
| HP:0011991 | Abnormal neutrophil count | |
| HP:0025395 | Combined cystic and ground-glass pattern on pulmonary HRCT | |
| HP:0002875 | Exertional dyspnea | |
| HP:0002721 | Immunodeficiency | |
| HP:0010702 | Increased circulating immunoglobulin concentration | |
| HP:0006515 | Interstitial pneumonitis | |
| HP:0031246 | Nonproductive cough | |
| HP:0002202 | Pleural effusion | |
| HP:0002878 | Respiratory failure | |
| HP:0004887 | Respiratory failure requiring assisted ventilation | |
| HP:0002093 | Respiratory insufficiency | |
| HP:0001824 | Weight loss | |
| Occasional (29-5%) | ||
| HP:0031863 | Bloodstream infectious agent | |
| HP:0009098 | Chronic oral candidiasis | |
| HP:0025435 | Increased circulating lactate dehydrogenase concentration | |
| HP:0005948 | Multiple pulmonary cysts | |
| HP:0002664 | Neoplasm | |
| HP:0032177 | Parenchymal consolidation | |
Run the differential on the 5 obligate / very frequent terms
Annotation source: 26281787[PMID]_16255399[PMID]_23209406[PMID]_29635251[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/723
- This record as JSON: /data/d/723.json