CANOMAD syndrome
Synonyms: CANDA syndrome · Chronic ataxic neuropathy-ophthalmoplegia-IgM paraprotein-cold agglutinins-disialosyl antibodies syndrome · Chronic sensory ataxic neuropathy with anti-disialosyl IgM antibodies
- Type
- Disease
- Group
- Disorder
- Age of onset
- Adult, Elderly
- Status
- active
A rare chronic immune-mediated polyneuropathy characterized by a progressive disabling neuropathy with marked gait disturbance primarily due to sensory ataxia with concurrent cranial neuropathies (internal or external ophthalmoplegia, dysphagia, dysarthria, or facial weakness) and anti-disialosyl IgM antibodies.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | CANOMAD syndrome | CANDA syndrome · Chronic ataxic neuropathy-ophthalmoplegia-IgM paraprotein-cold agglutinins-disialosyl antibodies syndrome · Chronic sensory ataxic neuropathy with anti-disialosyl IgM antibodies |
| fr | Syndrome CANOMAD | Ataxie chronique neuropathique avec anticorps IgM anti-disialosyl · Neuropathie ataxiante avec IgM anti-gangliosides disialylés · Syndrome CANDA · Syndrome d'ataxie chronique neuropathique-ophtalmoplégie-paraprotéine IgM-cryoagglutinines-anticorps disialylés |
| de | CANOMAD-Syndrom | CANDA-Syndrom · Chronisch-ataxische Neuropathie-Ophtalmoplegie-IgM-Paraprotein-Kälteagglutination-Disialosyl-Antikörper-Syndrom · Neuropathie, ataxische chronische sensorische mit Anti-Disialosyl IgM-Antikörper |
| es | Síndrome CANOMAD | Neuropatía crónica atáxica sensorial con anticuerpos IgM antidisialosil · Síndrome CANDA · Síndrome de neuropatía atáxica crónica-oftalmoplejía-paraproteína IgM-aglutininas frías-anticuerpos disialosil |
| it | Sindrome CANOMAD | Neuropatia atassica cronica - oftalmoplegia - paraproteina IgM - crioagglutinine - anticorpi anti-disialosil · Neuropatia atassica sensitiva cronica associata ad anticorpi anti-dialosil IgM |
| nl | CANOMAD-syndroom | CANDA-syndroom · Chronische ataxische neuropathie - oftalmoplegie - IgM-paraproteïne - koude agglutininen - disialosylantilichamen-syndroom · Chronische sensorische ataxische neuropathie met anti-dyalosyl IgM-antilichamen |
| pt | Síndrome CANOMAD | Neuropatia crónica atáxica - oftalmoplegia - paraproteína IgM - aglutininas frias - anticorpos anti-dissialosil |
| pl | Zespół CANOMAD | Przewlekła neuropatia czuciowa z przeciwciałami IgM przeciwko disialogangliozydom · Przewlekła neuropatia z ataksją - oftalmoplegia - paraproteiny IgM - zimne aglutyniny - przeciwciała przeciwko disialylowanym gangliozydom |
| cs | CANOMAD syndrom | Syndrom zahrnující chronickou ataktickou neuropatii, oftalmoplegii, IgM paraprotein-studené aglutininy a disialosylové protilátky · Chronická senzorická ataktická neuropatie s anti-dyalosylovými IgM protilátkami |
| uk | Синдром CANOMAD | Синдром CANDA · Синдром хронічної атаксичної нейропатії - офтальмоплегії - парапротеїн IgM - холодові аглютиніни - дисіалозильних антитіл · Хронічна сенсорна атаксична нейропатія з антидізіалозильними IgM антитілами |
| zh | CANOMAD综合征 | 慢性共济失调性神经病-眼肌麻痹-IgM副蛋白-冷凝集素-disialosyl抗体综合征 |
| tr | CANOMAD sendromu | CANDA sendromu · Anti-disialosil IgM antikorları ile seyreden kronik duyusal ataksik nöropati · Kronik ataksik nöropati-oftalmopleji-IgM paraprotein-soğuk aglutininler-disialosil antikorları sendromu |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | G61.8 | NTBT | attributed | validated |
| ICD-11 | 8C01.3 | NTBT | index | validated |
| MONDO | 0019109 | E | validated | |
| MeSH | C537980 | E | validated | |
| UMLS | C2931684 | E | validated | |
| GARD | 9778 | E | validated | |
| MedDRA | 10088816 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (3):
- ORPHA:208974Chronic acquired demyelinating polyneuropathy
rare neurological diseases - ORPHA:209010Peripheral neuropathy associated with monoclonal gammopathy
rare neurological diseases - ORPHA:182064Rare neuroinflammatory or neuroimmunological disease
rare neurological diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
2 records| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | <1 / 1 000 000 | — | Worldwide | Class only | Validated | ORPHANET_[EXPERT] |
| Cases/families | 100 cases | Worldwide | Case(s) | Validated | [EXPERT] |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
Orphanet has no HPO annotation for this code in this release.
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/71279
- This record as JSON: /data/d/71279.json