Plague
Synonyms: Y. pestis infection · Yersinia pestis infection
- Type
- Disease
- Group
- Disorder
- Age of onset
- All ages
- Status
- active
A rare zoonotic disease characterized by life-threatening, highly contagious and rapidly progressing infection caused by the Gram-negative bacterium <i>Yersinia pestis</i>, affecting rodents, and transmitted to human accidentally. It manifests differently depending on the route of infection. Bubonic plague results from the bite of an infected rodent flea. Pneumonic plague, less frequent but more dangerous, may arise through inhalation of infectious droplets or spread of bubonic plague to the lungs. Septicemic plague occurs from dissemination into the bloodstream, either as a primary infection or as a complication of bubonic or pneumonic forms, leading to disseminated intravascular coagulation, necrosis, and multi-organ failure.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Plague | Y. pestis infection · Yersinia pestis infection |
| fr | Peste | Infection à Y. pestis · Infection à Yersinia pestis |
| de | Pest | Yersinia pestis-Infektion |
| es | Peste | Infección por Y. pestis · Infección por Yersinia pestis · Yersiniosis |
| it | Peste | Infezione da Y.pestis · Infezione da Yersinia pestis |
| nl | Pest | Infectie door Y. pestis · Infectie door Yersinia pestis |
| pt | Peste | Infeção por Y. pestis · Infeção por Yersinia pestis |
| pl | Dżuma | Jersinioza |
| cs | Mor | Yersinióza |
| uk | Чума | Інфекція Y. pestis · Інфекція Yersinia pestis |
| zh | 鼠疫 | 耶尔森菌病 |
| tr | Veba | Yersiniyoz |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | A20.0 | BTNT | specific | validated |
| ICD-10 | A20.1 | BTNT | specific | validated |
| ICD-10 | A20.2 | BTNT | specific | validated |
| ICD-10 | A20.3 | BTNT | specific | validated |
| ICD-10 | A20.7 | BTNT | specific | validated |
| ICD-10 | A20.8 | BTNT | specific | validated |
| ICD-10 | A20.9 | BTNT | specific | validated |
| ICD-11 | 1B93 | E | specific | validated |
| MONDO | 0019095 | E | validated | |
| MeSH | D010930 | E | validated | |
| UMLS | C0032064 | E | validated | |
| MedDRA | 10035148 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:659712Rare yersiniosis
rare infectious diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
5 records| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only | Not yet validated | ORPHANET |
| Annual incidence | 1-9 / 100 000 | 2.2 / 100 000 | Europe | Value and class | Validated | European Centre for Disease prevention and Control 2011[OTHER] |
| Cases/families | 237 cases | Africa | Case(s) | Validated | World Health Organization 2019[OTHER] | |
| Cases/families | 6 cases | Latin America | Case(s) | Validated | World Health Organization 2019[OTHER] | |
| Cases/families | 2 cases | South East Asia | Case(s) | Validated | World Health Organization 2019[OTHER] |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
55 annotations · validated 2019-11-18| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0012378 | Fatigue | |
| HP:0001945 | Fever | |
| HP:0002840 | Lymphadenitis | |
| Frequent (79-30%) | ||
| HP:0008066 | Abnormal blistering of the skin | |
| HP:0002039 | Anorexia | |
| HP:0000739 | Anxiety | |
| HP:0031864 | Bacteremia | |
| HP:0020084 | Carbuncle | |
| HP:0100749 | Chest pain | |
| HP:0025143 | Chills | |
| HP:0030953 | Conjunctival hyperemia | |
| HP:0031258 | Delirium | |
| HP:0000958 | Dry skin | |
| HP:0002315 | Headache | |
| HP:0002240 | Hepatomegaly | |
| HP:0011355 | Localized skin lesion | |
| HP:0004372 | Reduced consciousness | |
| HP:0200042 | Skin ulcer | |
| HP:0001744 | Splenomegaly | |
| HP:0001649 | Tachycardia | |
| Occasional (29-5%) | ||
| HP:0002027 | Abdominal pain | |
| HP:0001892 | Abnormal bleeding | |
| HP:0009811 | Abnormality of the elbow | |
| HP:0011949 | Acute infectious pneumonia | |
| HP:0011675 | Arrhythmia | |
| HP:0002829 | Arthralgia | |
| HP:0025085 | Bloody diarrhea | |
| HP:0040181 | Chapped lip | |
| HP:0001259 | Coma | |
| HP:0000716 | Depression | |
| HP:0002014 | Diarrhea | |
| HP:0000969 | Edema | |
| HP:0025043 | Enlarged mesenteric lymph node | |
| HP:0004387 | Enterocolitis | |
| HP:0012219 | Erythema nodosum | |
| HP:0000206 | Glossitis | |
| HP:0000365 | Hearing impairment | |
| HP:0002248 | Hematemesis | |
| HP:0002105 | Hemoptysis | |
| HP:0002615 | Hypotension | |
| HP:0032564 | Ileitis | |
| HP:0002037 | Inflammation of the large intestine | |
| HP:0011499 | Mydriasis | |
| HP:0002098 | Respiratory distress | |
| HP:0100806 | Sepsis | |
| HP:0000988 | Skin rash | |
| HP:0001350 | Slurred speech | |
| HP:0002317 | Unsteady gait | |
| HP:0002013 | Vomiting | |
| Very rare (<4-1%) | ||
| HP:0001369 | Arthritis | |
| HP:0100584 | Endocarditis | |
| HP:0100533 | Inflammatory abnormality of the eye | |
| HP:0001287 | Meningitis | |
| HP:0001324 | Muscle weakness | |
| HP:0025439 | Pharyngitis | |
Run the differential on the 3 obligate / very frequent terms
Annotation source: 27722868[PMID]_29070654[PMID]_29628173[PMID]_26004640[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/707
- This record as JSON: /data/d/707.json