Bronchopulmonary dysplasia
Synonyms: BPD
- Type
- Malformation syndrome
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- Infancy, Neonatal
- Status
- active
Bronchopulmonary dysplasia is a chronic respiratory disease that results from complications related to lung injury during the treatment of infant acute respiratory distress syndrome in low-birth-weight premature infants or from abnormal lung development in older infants. Clinical signs are tachypnea, tachycardia and signs of respiratory distress such as intercostal recession, grunting and nasal flaring.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Bronchopulmonary dysplasia | BPD |
| fr | Dysplasie broncho-pulmonaire | |
| de | Dysplasie, bronchopulmonale | = en |
| es | Displasia broncopulmonar | DBP |
| it | Displasia broncopolmonare | = en |
| nl | Bronchopulmonale dysplasie | = en |
| pt | Displasia broncopulmonar | DBP |
| pl | Dysplazja oskrzelowo-płucna | = en |
| cs | Bronchopulmonální dysplázie | = en |
| uk | Бронхолегенева дисплазія | = en |
| zh | 支气管肺发育不良 | = en |
| tr | Bronkopulmoner displazi | = en |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | P27.1 | E | specific | validated |
| ICD-11 | KB29.0 | E | specific | validated |
| MONDO | 0019091 | E | validated | |
| MeSH | D001997 | E | validated | |
| UMLS | C0006287 | E | validated | |
| GARD | 5962 | E | validated | |
| MedDRA | 10006475 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (2):
- ORPHA:108993Non-syndromic respiratory or mediastinal malformation
rare developmental anomalies during embryogenesis; rare surgical thoracic diseases - ORPHA:182111Respiratory malformation
rare respiratory diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | 1-5 / 10 000 | 13 / 100 000 | Europe | Value and class | Validated | European Medicines Agency[OTHER] |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
27 annotations · validated 2024-02-01| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0002088 | Abnormal lung morphology | |
| HP:0006528 | Chronic lung disease | |
| HP:0012735 | Cough | |
| HP:0002094 | Dyspnea | |
| HP:0002097 | Emphysema | |
| HP:0012419 | Hyperoxemia | |
| HP:0001622 | Premature birth | |
| HP:0002098 | Respiratory distress | |
| HP:0004887 | Respiratory failure requiring assisted ventilation | |
| HP:0001518 | Small for gestational age | |
| Frequent (79-30%) | ||
| HP:0012252 | Abnormal respiratory system morphology | |
| HP:0002795 | Abnormal respiratory system physiology | |
| HP:0006536 | Airway obstruction | |
| HP:0002780 | Bronchomalacia | |
| HP:0002871 | Central apnea | |
| HP:0006597 | Diaphragmatic paralysis | |
| HP:0004890 | Elevated pulmonary artery pressure | |
| HP:0001708 | Right ventricular failure | |
| HP:0001667 | Right ventricular hypertrophy | |
| HP:0002360 | Sleep abnormality | |
| HP:0001607 | Subglottic stenosis | |
| HP:0030828 | Wheezing | |
| Occasional (29-5%) | ||
| HP:0030878 | Abnormality on pulmonary function testing | |
| HP:0100750 | Atelectasis | |
| HP:0003546 | Exercise intolerance | |
| HP:0100632 | Pulmonary sequestration | |
| HP:0002786 | Tracheobronchomalacia | |
Run the differential on the 10 obligate / very frequent terms
Annotation source: 26593076[PMID]_28067830[PMID]_28090255[PMID]_27806990[PMID]_26593086[PMID]_34670756[PMID]_32854293[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/70589
- This record as JSON: /data/d/70589.json