Small cell lung cancer
Synonyms: SCLC
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- Adult
- Status
- active
Small cell lung cancer (SCLC) is a highly aggressive malignant neoplasm, accounting for 10-15% of lung cancer cases, characterized by rapid growth, and early metastasis. SCLC usually manifests as a large hilar mass with bulky mediastinal lymphadenopathy presenting clinically with chest pain, persistent cough, dyspnea, wheezing, hoarseness, hemoptysis, loss of appetite, weight loss, and neurological and endocrine paraneoplastic syndromes. SCLC is primarily reported in elderly people with a history of long-term tobacco exposure.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Small cell lung cancer | SCLC |
| fr | Cancer du poumon à petites cellules | |
| de | Bronchialkarzinom, kleinzelliges | Lungenkrebs, kleinzelliger · SCLC |
| es | Cáncer de pulmón de células pequeñas | CPCP · Cáncer de pulmón microcítico |
| it | Cancro del polmone a piccole cellule | = en |
| nl | Kleincellige longkanker | = en |
| pt | Cancro pulmonar de células pequenas | CPCP |
| pl | Drobnokomórkowy rak płuc | = en |
| cs | Malobuněčný karcinom plic | = en |
| uk | Дрібноклітинний рак легенів | = en |
| zh | 小细胞肺癌 | = en |
| tr | Küçük hücreli akciğer kanseri | = en |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| OMIM | 182280 | E | validated | |
| ICD-10 | C34.9 | NTBT | attributed | validated |
| ICD-11 | 2C25.1 | E | specific | validated |
| MONDO | 0008433 | E | validated | |
| UMLS | C0149925 | E | validated | |
| GARD | 9344 | E | validated | |
| MedDRA | 10041067 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:101945Rare bronchopulmonary and pleural cavity tumors
rare respiratory diseases; rare neoplastic diseases
No children.
Genes
3 direct| Gene | Association | Status | HGNC | Ensembl | OMIM | Locus | Name | Source of validation |
|---|---|---|---|---|---|---|---|---|
| RB1 | Disease-causing somatic mutation(s) in | Assessed | HGNC:9884 | ENSG00000139687 | 614041 | 13q14.2 | RB transcriptional corepressor 1 | 26168399[PMID] |
| TP53 | Disease-causing somatic mutation(s) in | Assessed | HGNC:11998 | ENSG00000141510 | 191170 | 17p13.1 | tumor protein p53 | 26168399[PMID] |
| TP73 | Disease-causing somatic mutation(s) in | Assessed | HGNC:12003 | ENSG00000078900 | 601990 | 1p36.32 | tumor protein p73 | 26168399[PMID] |
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | 1-5 / 10 000 | 12 / 100 000 | Europe | Value and class | Validated | European Medicines Agency 2018[OTHER] |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
Orphanet has no HPO annotation for this code in this release.
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/70573
- This record as JSON: /data/d/70573.json