Warty dyskeratoma
Synonyms: Follicular dyskeratoma
- Type
- Disease
- Group
- Disorder
- Inheritance
- Unknown
- Age of onset
- Adult
- Status
- active
A rare, benign, epidermal disease characterized by a solitary, asymptomatic, verrucous, skin-coloured to red-brown papule or nodule, which contains a central pore and keratotic plug, occuring most frequently on the scalp, face and neck (rarely, in the mouth, under the nail plate or on the mons pubis). Occasionally, lesions may be multiple and/or pruritic. Histologically, a well-circumscribed, cup-shaped, keratin-filled invagination, with prominent acantholytic dyskeratosis, suprabasilar clefts and villi projecting into the clefts, is observed.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Warty dyskeratoma | Follicular dyskeratoma |
| fr | Dyskératome verruqueux | Dyskératome folliculaire |
| de | Dyskeratom, warziges | Dyskeratosis follicularis isolata |
| es | Disqueratoma verrucoso | Disqueratoma folicular |
| it | Discheratoma verrucoso | Discheratoma follicolare |
| nl | Wratachtig dyskeratoom | Folliculair dyskeratoom |
| pt | Disqueratoma verrugoso | Disqueratoma folicular |
| pl | Dyskeratoma brodawkowata | Dyskeratoma pęcherzykowa |
| cs | Bradavčitý dyskeratom | Folikulární dyskeratom · Solitární m. Darier |
| uk | Бородавчаста дискератома | Фолікулярна дискератома |
| zh | 疣性角化不良瘤 | 滤泡角膜瘤 |
| tr | Siğilli diskeratom | Foliküler diskeratom |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | L85.8 | NTBT | attributed | validated |
| ICD-11 | 2F21.Y | NTBT | index | validated |
| ICD-11 | XH65S7 | E | specific | validated |
| MONDO | 0019077 | E | validated | |
| UMLS | C0334063 | E | validated | |
| MedDRA | 10068856 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:79359Other epidermal disorder
rare skin diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only | Not yet validated | ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
19 annotations · validated 2021-09-16| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0031285 | Abnormal perifollicular morphology | |
| HP:0100792 | Acantholysis | |
| HP:0011368 | Epidermal thickening | |
| HP:0011355 | Localized skin lesion | |
| Frequent (79-30%) | ||
| HP:0000464 | Abnormality of the neck | |
| HP:0001965 | Abnormality of the scalp | |
| HP:0200016 | Acrokeratosis | |
| HP:0030350 | Erythematous papule | |
| HP:0025512 | Skin-colored papule | |
| HP:0025103 | Umbilicated nodule | |
| Occasional (29-5%) | ||
| HP:0410340 | Focal epithelial hyperplasia of oral mucosa | |
| HP:0031445 | Oral mucosa nodule | |
| Very rare (<4-1%) | ||
| HP:0001892 | Abnormal bleeding | |
| HP:0001231 | Abnormal fingernail morphology | |
| HP:0100737 | Abnormal hard palate morphology | |
| HP:0006477 | Abnormality of the alveolar ridges | |
| HP:0012881 | Abnormality of the labia majora | |
| HP:0100648 | Neoplasm of the tongue | |
| HP:0030416 | Vulvar neoplasm | |
Run the differential on the 4 obligate / very frequent terms
Annotation source: 28831426[PMID]_28326204[PMID]_32670533[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/69745
- This record as JSON: /data/d/69745.json