Amoebiasis due to free-living amoebae
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- All ages
- Status
- active
A rare parasitic disease caused by free-living amoebae belonging to the <i>Acanthamoeba, Naegleria</i> and <i>Balamuthia genera</i>, that are able to survive in an autonomous state in all natural environments and can also parasitize humans. In immunosuppressed individuals <i>Acanthamoeba</i> genus contamination leads to granulomatous amoebic encephalitis (also reported in association with species of the <i>Balamuthia</i> genus) together with other problems including cardiac, cutaneous and pulmonary manifestations, all of which influence the prognosis. In immunocompetent individuals, the <i>Naegleria fowleri</i> species is responsible for primary amoebic meningoencephalitis, the evolution of which is rapidly fatal.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Amoebiasis due to free-living amoebae | |
| fr | Amibiase à amibes libres | |
| de | Amöbiasis durch frei vorkommende Amöben | |
| es | Amebiasis por amebas de vida libre | |
| it | Amebiasi con amebe libere | |
| nl | Amoebiase door vrijlevende amoeben | Amoebiasis door vrijlevende amoeben |
| pt | Amebíase por amebas de vida livre | |
| pl | Ameboza wywołana wolno żyjącą amebą | |
| cs | Amébóza způsobená volně žijícími amébami | |
| uk | Амебіаз, спричинений вільноживучими амебами | |
| zh | 自由生活阿米巴所致阿米巴病 | |
| tr | Serbest yaşayan amiplere bağlı amipiyaz |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | B60.1 | BTNT | specific | validated |
| ICD-10 | B60.2 | BTNT | specific | validated |
| ICD-11 | 1A36.11 | BTNT | specific | validated |
| ICD-11 | 1A36.12 | BTNT | specific | validated |
| ICD-11 | 1A36.1Y | BTNT | specific | validated |
| MONDO | 0019036 | E | validated | |
| UMLS | C0153326 | E | validated | |
| GARD | 12650 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (2):
- ORPHA:98010Infectious disease of the nervous system
rare neurological diseases - ORPHA:163588Rare parasitic disease
rare infectious diseases
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | 1-9 / 100 000 | — | Europe | Class only | Validated | [EXPERT] |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
68 annotations · validated 2020-04-14| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Frequent (79-30%) | ||
| HP:0002921 | Abnormality of the cerebrospinal fluid | |
| HP:0000708 | Atypical behavior | |
| HP:0410263 | Brain imaging abnormality | |
| HP:0200149 | CSF lymphocytic pleiocytosis | |
| HP:0001945 | Fever | |
| HP:0002315 | Headache | |
| HP:0002922 | Increased CSF protein concentration | |
| HP:0002383 | Infectious encephalitis | |
| HP:0002018 | Nausea | |
| HP:0000751 | Personality changes | |
| HP:0000613 | Photophobia | |
| HP:0001250 | Seizure | |
| HP:0002013 | Vomiting | |
| Occasional (29-5%) | ||
| HP:0006897 | Abducens palsy | |
| HP:0002134 | Abnormal basal ganglia morphology | |
| HP:0012747 | Abnormal brainstem MRI signal intensity | |
| HP:0001317 | Abnormal cerebellum morphology | |
| HP:0002500 | Abnormal cerebral white matter morphology | |
| HP:0031910 | Abnormal cranial nerve physiology | |
| HP:0012286 | Abnormal hypothalamus morphology | |
| HP:0002418 | Abnormality of midbrain morphology | |
| HP:0002538 | Abnormality of the cerebral cortex | |
| HP:0011441 | Abnormality of the medulla oblongata | |
| HP:0007361 | Abnormality of the pons | |
| HP:0002143 | Abnormality of the spinal cord | |
| HP:0002381 | Aphasia | |
| HP:0002181 | Cerebral edema | |
| HP:0001289 | Confusion | |
| HP:0000651 | Diplopia | |
| HP:0000324 | Facial asymmetry | |
| HP:0010628 | Facial palsy | |
| HP:0007011 | Fourth cranial nerve palsy | |
| HP:0032252 | Granuloma | |
| HP:0001269 | Hemiparesis | |
| HP:0002721 | Immunodeficiency | |
| HP:0002516 | Increased intracranial pressure | |
| HP:0020059 | Increased red blood cell count | |
| HP:0000737 | Irritability | |
| HP:0001254 | Lethargy | |
| HP:0007185 | Loss of consciousness | |
| HP:0031179 | Nuchal rigidity | |
| HP:0012246 | Oculomotor nerve palsy | |
| HP:0000711 | Restlessness | |
| HP:0025258 | Stiff neck | |
| HP:0000572 | Visual loss | |
| Very rare (<4-1%) | ||
| HP:0000223 | Abnormality of taste sensation | |
| HP:0000834 | Abnormality of the adrenal glands | |
| HP:0011675 | Arrhythmia | |
| HP:0001251 | Ataxia | |
| HP:0000618 | Blindness | |
| HP:0001259 | Coma | |
| HP:0030953 | Conjunctival hyperemia | |
| HP:0100583 | Corneal perforation | |
| HP:0012804 | Corneal ulceration | |
| HP:0040197 | Encephalomalacia | |
| HP:0004409 | Hyposmia | |
| HP:0031731 | Increased tear production | |
| HP:0032620 | Intrarenal abscess | |
| HP:0001700 | Myocardial necrosis | |
| HP:0200026 | Ocular pain | |
| HP:0200034 | Papule | |
| HP:0002090 | Pneumonia | |
| HP:0200039 | Pustule | |
| HP:0011947 | Respiratory tract infection | |
| HP:0000246 | Sinusitis | |
| HP:0200042 | Skin ulcer | |
| HP:0001482 | Subcutaneous nodule | |
| HP:0032162 | Unusual skin infection | |
Annotation source: 28664704[PMID]_23829906[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/68
- This record as JSON: /data/d/68.json