Pruritic urticarial papules and plaques of pregnancy
Synonyms: PUPPP · Polymorphic eruption of pregnancy
- Type
- Disease
- Group
- Disorder
- Age of onset
- Adolescent, Adult
- Status
- active
A rare skin disease characterized by urticarial papules and plaques with severe pruritus mainly on the abdomen, buttocks, and proximal thighs. The condition usually develops during the third trimester of the first pregnancy, although presentation in the postpartum period, which may also feature other types of skin lesions, has been described in some cases. The symptoms generally resolve within few weeks.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Pruritic urticarial papules and plaques of pregnancy | PUPPP · Polymorphic eruption of pregnancy |
| fr | Plaques et papules prurigineuses urticariennes de la grossesse | Eruption polymorphe de la grossesse · PUPPP |
| de | Pruritische urtikarielle Papeln und Plaques in der Schwangerschaft | PUPPP · Schwangerschaftsdermatose, polymorphe |
| es | Pápulas urticariales pruriginosas y placas de embarazo | Erupción polimórfica del embarazo |
| it | Papule e placche orticarioidi pruriginose della gravidanza | Eruzione polimorfa della gravidanza |
| nl | Pruritische urticariële papels en plaques bij zwangerschap | PUPPP · Polymorfe eruptie bij zwangerschap |
| pt | Pápulas e placas pruriginosa urticárias da gravidez | Erupção polimórfica da gravidez |
| pl | Swędzące grudki i ogniska pokrzywkowe w przebiegu ciąży | Wielopostaciowe osutki ciążowe |
| cs | Pruritické urtikariální papuly a plaky v graviditě | Polymorfní erupce v těhotenství |
| uk | Сверблячі кропивяні папули та бляшки при вагітності | Поліморфні висипання під час вагітності · PUPPP |
| zh | 妊娠瘙痒性荨麻疹性丘疹及斑块 | 妊娠性多形疹 |
| tr | Gebeliğin döküntülü kaşıntısı | PUPPP · Gebelikte polimorfik patlama |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| OMIM | 178995 | E | validated | |
| ICD-10 | O26.8 | NTBT | attributed | validated |
| ICD-11 | JA65.12 | E | specific | validated |
| MONDO | 0008353 | E | validated | |
| MeSH | C535817 | E | validated | |
| UMLS | C0269680 | E | validated | |
| GARD | 9635 | E | validated | |
| MedDRA | 10066100 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (2):
- ORPHA:163637Rare disorder related with pregnancy, childbirth and puerperium
rare gynecological and obstetric diseases - ORPHA:79384Rare urticaria
rare skin diseases; rare allergic disease
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only | Validated | ORPHANET_27960565[PMID] |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
21 annotations · validated 2024-07-09| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0030350 | Erythematous papule | |
| HP:0000989 | Pruritus | |
| HP:0001065 | Striae distensae | |
| HP:0030351 | Urticarial plaque | |
| Frequent (79-30%) | ||
| HP:0025474 | Erythematous plaque | |
| HP:0004324 | Increased body weight | |
| HP:0001036 | Parakeratosis | |
| HP:0030898 | Pruritis on abdomen | |
| HP:0200037 | Skin vesicle | |
| Occasional (29-5%) | ||
| HP:0031538 | Abnormal dermoepidermal junction morphology | |
| HP:0100872 | Abnormality of the plantar skin of foot | |
| HP:0001041 | Facial erythema | |
| HP:0031248 | Palmar pruritus | |
| HP:0030899 | Pruritis on hand | |
| HP:0030900 | Pruritus on foot | |
| Very rare (<4-1%) | ||
| HP:0008066 | Abnormal blistering of the skin | |
| HP:0000964 | Eczematoid dermatitis | |
| HP:0025493 | Palmoplantar erythema | |
| HP:0030901 | Pruritis on breast | |
| Excluded (0%) | ||
| HP:0031541 | Linear C3 deposits along the epidermal basement membrane zone | |
| HP:0031540 | Linear IgG deposits along the epidermal basement membrane zone | |
Run the differential on the 4 obligate / very frequent terms
Annotation source: 9843004[PMID]_30969522[PMID]_22909357[PMID]_31903969[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/64745
- This record as JSON: /data/d/64745.json