Childhood-onset schizophrenia
Synonyms: COS · VEOS · Very early-onset schizophrenia
- Type
- Disease
- Group
- Disorder
- Inheritance
- Multigenic/multifactorial
- Age of onset
- Adolescent, Childhood
- Status
- active
A rare neurologic disease with psychiatric involvement characterized by prominent pre-psychotic developmental disabilities (cognitive, language, motor), socio-communicative disturbances, auditory hallucinations (visual and tactile hallucinations are rarer) preceding psychotic symptoms, presenting before 13 years of age. Co-occurrence of neurodevelopmental disorders (e.g. autism spectrum disorders, attention deficit hyperactivity disorder) is frequent. Disease course is more severe than adult-onset form of the disease, with major neurodevelopmental impact.
Names in Orphadata languages
10 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Childhood-onset schizophrenia | COS · VEOS · Very early-onset schizophrenia |
| fr | Schizophrénie à début infantile | SDTP |
| de | Schizophrenie im Kindesalter | Schizophrenie, früh beginnende |
| es | Esquizofrenia de inicio en la infancia | |
| it | Schizofrenia ad esordio infantile | COS · Schizofrenia ad esordio molto precoce · VEOS |
| nl | Schizofrenie beginnend op kinderleeftijd | COS · VEOS · Zeer vroeg optredende schizofrenie |
| pt | Esquizofrenia com início na infância | COS · Esquizofrenia de início muito precoce · VEOS |
| pl | Schizofrenia o początku w wieku dziecięcym | = en |
| cs | Schizofrenie s nástupem v dětství | = en |
| uk | Шизофренія з дебютом у дитинстві | COS · VEOS · Дуже рання шизофренія |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | F20.0 | BTNT | attributed | validated |
| ICD-10 | F20.1 | BTNT | attributed | validated |
| ICD-10 | F20.2 | BTNT | attributed | validated |
| ICD-10 | F20.3 | BTNT | attributed | validated |
| ICD-10 | F20.4 | BTNT | attributed | validated |
| ICD-10 | F20.5 | BTNT | attributed | validated |
| ICD-10 | F20.6 | BTNT | attributed | validated |
| ICD-10 | F20.8 | BTNT | attributed | validated |
| MONDO | 0957430 | E | validated | |
| MeSH | D012561 | E | validated | |
| UMLS | C0036346 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:98033Rare neurologic disease with psychiatric involvement
rare neurological diseases
No children.
Codes that Orphanet moved or referred to this one:
- ORPHA:96369OBSOLETE: Early-onset schizophrenia referred to · inactive
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
2 records| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Annual incidence | 1-5 / 10 000 | — | Europe | Class only | Validated | 22906158[PMID]_ORPHANET |
| Point prevalence | Unknown | — | Europe | Class only | Validated | 22906158[PMID]_ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
20 annotations · validated 2026-02-06| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0000709 | Psychosis | |
| Frequent (79-30%) | ||
| HP:0000745 | Abnormal diminished volition | |
| HP:0007018 | Attention deficit hyperactivity disorder | |
| HP:0000729 | Autistic behavior | |
| HP:0100543 | Cognitive impairment | |
| HP:0000746 | Delusion | |
| HP:5200310 | Diminishment of social interactions | |
| HP:0025769 | Disordered formal thought process | |
| HP:0000738 | Hallucinations | |
| HP:0033051 | Impaired executive functioning | |
| HP:0011999 | Paranoia | |
| Occasional (29-5%) | ||
| HP:0033511 | Addictive substance use | |
| HP:0000716 | Depression | |
| HP:0006892 | Frontotemporal cerebral atrophy | |
| HP:0001263 | Global developmental delay | |
| HP:0006956 | Lateral ventricle dilatation | |
| HP:0002300 | Mutism | |
| HP:0031589 | Suicidal ideation | |
| HP:5200330 | Suicide behaviors | |
| HP:0025784 | Word salad | |
Run the differential on the 1 obligate / very frequent terms
Annotation source: PNDS 2022[OTHER]_30969686[PMID]_38492329[PMID]_39867751[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/641496
- This record as JSON: /data/d/641496.json