Immunotherapy induced hypophysitis
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- All ages
- Status
- active
A rare acquired pituitary hormone deficieny characterized by inflammation of the pituitary gland secondary to immunotherapy for cancers treatments (such as monoclonal antibodies against cytotoxic T lymphocytes antigen, programmed cell death protein-1, and programmed cell death ligand molecules). Major clinical features include headache, fatigue, adrenal insufficiency and hypothyroidism. Patients may also have nausea and vomiting associated to the headache as well as dizziness and hot flashes. Enlargement of the pituitary gland is present in the brain imaging.
Names in Orphadata languages
10 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Immunotherapy induced hypophysitis | |
| fr | Hypophysite induite par l'immunothérapie | |
| de | Hypophysitis, Immuntherapie-induzierte | |
| es | Hipofisitis inducida por inmunoterapia | |
| it | Ipofisite indotta dallimmunoterapia | |
| nl | Hypofysitis geïnduceerd door immuuntherapie | |
| pt | Hipofisite induzida por imunoterapia | |
| pl | Zapalenie przysadki mózgowej wywołane immunoterapią | |
| cs | Hypofyzitida vyvolaná imunoterapií | |
| uk | Гіпофізит, спричинений імунотерапією |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | E89.3 | NTBT | attributed | validated |
| ICD-11 | 5A61.0 | NTBT | attributed | validated |
| MONDO | 0957423 | E | validated | |
| UMLS | C5816794 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:95502Acquired pituitary hormone deficiency
rare endocrine diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
2 records| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Annual incidence | 1-5 / 10 000 | 12.8074 / 100 000 | Europe | Value and class | Validated | 28702249[PMID]_34430146[PMID] |
| Point prevalence | Unknown | — | Europe | Class only | Validated | 28702249[PMID]_34430146[PMID]_ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
Orphanet has no HPO annotation for this code in this release.
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/641350
- This record as JSON: /data/d/641350.json