Multifocal motor neuropathy
Synonyms: MMN · MMNCB · Multifocal motor neuropathy with conduction block
- Type
- Disease
- Group
- Disorder
- Inheritance
- Unknown
- Age of onset
- Adult
- Status
- active
Multifocal motor neuropathy (MMN) is a rare acquired immune-mediatedneuropathy characterized clinically by a purely motor deficit with conduction block and asymmetric multifocal weakness, fasciculations, and cramping.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Multifocal motor neuropathy | MMN · MMNCB · Multifocal motor neuropathy with conduction block |
| fr | Neuropathie motrice multifocale | MMN · MMNCB · NMMBC · Neuropathie motrice multifocale à bloc de conduction |
| de | Multifokale motorische Neuropathie | MMN · MMNCB · Neuropathie, motorische multifokale mit Reizleitungs-Störung |
| es | Neuropatía motora multifocal | MMN · MMNCB · Neuropatía motora multifocal con bloqueos de la conducción |
| it | Neuropatia motoria multifocale | MMN · MMNCB · Neuropatia motoria multifocale con blocco di conduzione |
| nl | Multifocale motorische neuropathie | MMN · MMNCB · Multifocale motorische neuropathie met geleidingsblok |
| pt | Neuropatia motora multifocal com bloqueio de condução | |
| pl | Wieloogniskowa neuropatia ruchowa | MMN · MMNCB · Wieloogniskowa neuropatia ruchowa z blokiem przewodzenia |
| cs | Multifokální motorická neuropatie | MMN · MMNCB · Multifokální motorická neuropatie s blokem vedení |
| uk | Мультифокальна моторна нейропатія | MMN · MMNCB · Мультифокальна моторна нейропатія з блокадою провідності |
| zh | 多灶性运动神经病 | 多灶性运动神经病伴传导阻滞 |
| tr | Multifokal motor nöropati | MMN · MMNCB · İletim bloklu multifokal motor nöropati |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | G61.8 | NTBT | attributed | validated |
| ICD-11 | 8C01.3 | NTBT | index | validated |
| MONDO | 0018979 | E | validated | |
| UMLS | C0393847 | E | validated | |
| GARD | 11011 | E | validated | |
| MedDRA | 10065579 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:208974Chronic acquired demyelinating polyneuropathy
rare neurological diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
2 records| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | 1-9 / 100 000 | 1.5 / 100 000 | Worldwide | Value and class | Validated | 17075524[PMID]_11282149[PMID]_23623583[PMID] |
| Point prevalence | 1-9 / 1 000 000 | 0.16 / 100 000 | Japan | Value and class | Validated | 23196468[PMID] |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
12 annotations · validated 2018-02-01| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0009063 | Progressive distal muscle weakness | |
| Frequent (79-30%) | ||
| HP:0004345 | Abnormality of ganglioside metabolism | |
| HP:0002380 | Fasciculations | Diagnostic criterion |
| HP:0004302 | Functional motor deficit | |
| HP:0002922 | Increased CSF protein concentration | |
| HP:0003690 | Limb muscle weakness | Diagnostic criterion |
| HP:0006251 | Limited wrist extension | |
| HP:0012078 | Motor conduction block | |
| HP:0003394 | Muscle spasm | Diagnostic criterion |
| HP:0003323 | Progressive muscle weakness | |
| HP:0001315 | Reduced tendon reflexes | Diagnostic criterion |
| HP:0009077 | Weakness of long finger extensor muscles | |
Run the differential on the 1 obligate / very frequent terms
Annotation source: 24741315[PMID]_24395647[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/641
- This record as JSON: /data/d/641.json