Multisystem inflammatory syndrome in children and adults
Synonyms: MIS-C/A
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- Childhood
- Status
- active
A rare systemic disease characterized by a life-threatening hyperinflammatory state several weeks after infection with SARS-CoV-2, predominantly occurring in children. The primary infection is typically mild or asymptomatic, and patients are generally previously healthy individuals. Typical presenting signs and symptoms are persistent fever, gastrointestinal symptoms, mucocutaneous inflammation, lymphopenia, and high levels of circulating inflammatory markers. Some patients develop severe disease with cardiac involvement, hypotension, and shock. Presentation is similar in adults, although the severity of cardiac dysfunction, incidence of thrombosis, and mortality may be higher.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Multisystem inflammatory syndrome in children and adults | MIS-C/A |
| fr | Syndrome inflammatoire multisystémique chez l'enfant et l'adulte | = en |
| de | Multisystemisches inflammatorisches Syndrom bei Kindern und Erwachsenen | MIS-A · MIS-C · MIS-C/A · PIMS · PIMS-TS · Pädiatrisches hyperinflammatorisches Syndrom mit Multiorganbeteiligung |
| es | Síndrome inflamatorio multisistémico en la infancia y la edad adulta | SIM-A · SIM-C · SIM-C/A · SIMP · SIMP-TS · Síndrome inflamatorio multisistémico pediátrico |
| it | Sindrome infiammatoria multisistemica del bambino e dell'adulto | MIS-A · MIS-C · MIS-C/A · PIMS · PIMS-TS · Sindrome infiammatoria multisistemica pediatrica |
| nl | Multisystemisch inflammatoir syndroom bij kinderen en volwassenen | = en |
| pt | Síndrome inflamatório multissistémico em crianças e adultos | PIMS · Síndrome inflamatório multissistémico pediátrico |
| pl | Wieloukładowy zespół zapalny u dzieci i dorosłych | PIMS · MIS-A · MIS-C · MIS-C/A · PIMS-TS · Pediatryczny wieloukładowy zespół zapalny |
| cs | Multisystémový zánětlivý syndrom u dětí a dospělých | = en |
| uk | Мультисистемний запальний синдром у дітей та дорослих | = en |
| zh | Multisystem inflammatory syndrome in children and adults | = en |
| tr | Multisystem inflammatory syndrome in children and adults | = en |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | U10.9 | NTBT | inclusion | validated |
| ICD-11 | RA03 | NTBT | index | validated |
| MONDO | 0035375 | E | validated | |
| UMLS | C5680268 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (2):
- ORPHA:280373Rare pediatric systemic disease
rare systemic or rheumatologic diseases of childhood - ORPHA:182222Rare systemic disease
rare systemic and rheumatological diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
2 records| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Annual incidence | Unknown | — | Worldwide | Class only | Validated | 33640145[PMID] |
| Point prevalence | Unknown | — | Worldwide | Class only | Validated | 33640145[PMID] |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
Orphanet has no HPO annotation for this code in this release.
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/598363
- This record as JSON: /data/d/598363.json