Macrophagic myofasciitis
Synonyms: MMF
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- Adolescent, Adult, Childhood, Elderly
- Status
- active
A rare acquired skeletal muscle disease characterized by infiltration of the epimysium, perimysium, and perifascicular endomysium by macrophages with crystal inclusions composed of aluminum salts at the site of a previous vaccination (most commonly the deltoid muscle). Muscle necrosis is typically absent. Patients may present with myalgias, arthralgias, muscle weakness, chronic fatigue, asthenia, fever, and cognitive dysfunction. Signs and symptoms usually develop slowly over several months.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Macrophagic myofasciitis | MMF |
| fr | Myofasciite à macrophages | MFM · MMF |
| de | Makrophagische Myofasziitis | = en |
| es | Miofascitis macrofágica | |
| it | Miofascite macrofagica | MMF · Sindrome autoimmune/infiammatoria indotta da granuloma persistente da alluminio |
| nl | Macrofagische myofasciitis | = en |
| pt | Miofasceíte macrofágica | |
| pl | Makrofagowe zapalenie powięzi i mięśni | MMF · Zespół autozapalenia/zespół zapalny indukowany adjuwantem z przetrwałego ziarniniaka aluminiowego |
| cs | Makrofagická myofasciitida | MMF · Autoimunní/zánětlivé onemocnění indukované adjuvancií s perzistujícími hliníkovými granulomaty |
| uk | Макрофагальний міофасцит | = en |
| zh | 巨噬细胞肌筋膜炎 | = en |
| tr | Makrofajik miyofasit | = en |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | M60.8 | NTBT | attributed | validated |
| MONDO | 0018942 | E | validated | |
| MeSH | C537829 | E | validated | |
| UMLS | C2931639 | E | validated | |
| GARD | 176 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:206638Acquired skeletal muscle disease
rare neurological diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only | Not yet validated | ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
6 annotations · validated 2016-06-01| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0002829 | Arthralgia | |
| HP:0012378 | Fatigue | |
| HP:0001945 | Fever | |
| HP:0003324 | Generalized muscle weakness | |
| HP:0003326 | Myalgia | |
| Occasional (29-5%) | ||
| HP:0003457 | EMG abnormality | |
Run the differential on the 5 obligate / very frequent terms
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/592
- This record as JSON: /data/d/592.json