Methotrexate toxicity
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- All ages
- Status
- active
A rare intoxication characterized by acute renal tubular toxicity due to crystallization of methotrexate in the renal tubular lumen (which in turn leads to impaired methotrexate clearance and further deterioration of renal function and exacerbation of non-renal adverse events), myelosuppression with pancytopenia, gastrointestinal mucositis, maculopapular skin rash, chemical conjunctivitis, hepatotoxicity (reversible chemical hepatitis and hyperbilirubinemia), pulmonary toxicity, and, in severe cases, multiorgan failure. Central nervous system involvement, including headaches, seizures, and stroke-like symptoms, may also be observed.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Methotrexate toxicity | |
| fr | Toxicité au méthotrexate | |
| de | Methotrexat-Toxizität | |
| es | Toxicidad por metotrexato | |
| it | Tossicità da metotressato | |
| nl | Methotrexaat-toxiciteit | |
| pt | Toxicidade a metotrexato | |
| pl | Toksyczność Metotreksatu | |
| cs | Toxicita metotrexátu | |
| uk | Токсичність метотрексату | |
| zh | 甲氨蝶呤毒性 | |
| tr | Metotreksat toksisitesi |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | Y14 | NTBT | attributed | validated |
| ICD-11 | NE60 | NTBT | attributed | validated |
| MONDO | 0034212 | E | validated | |
| UMLS | C0568062 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:306640Rare intoxication due to medical products
rare disorders due to toxic effects
No children.
Codes that Orphanet moved or referred to this one:
- ORPHA:90070OBSOLETE: Methotrexate poisoning referred to · inactive
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | 1-9 / 100 000 | 3 / 100 000 | Europe | Value and class | Validated | European Medicines Agency 2015[OTHER] |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
22 annotations · validated 2024-10-03| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Frequent (79-30%) | ||
| HP:0002027 | Abdominal pain | |
| HP:0001410 | Decreased liver function | |
| HP:0002910 | Elevated circulating hepatic transaminase concentration | |
| HP:0002013 | Vomiting | |
| Occasional (29-5%) | ||
| HP:0001596 | Alopecia | |
| HP:0001394 | Cirrhosis | |
| HP:0001289 | Confusion | |
| HP:0002329 | Drowsiness | |
| HP:0012378 | Fatigue | |
| HP:0001945 | Fever | |
| HP:0002239 | Gastrointestinal hemorrhage | |
| HP:0002315 | Headache | |
| HP:0006515 | Interstitial pneumonitis | |
| HP:0001882 | Leukopenia | |
| HP:0001889 | Megaloblastic anemia | |
| HP:0002018 | Nausea | |
| HP:0000155 | Oral ulcer | |
| HP:0001733 | Pancreatitis | |
| HP:0000083 | Renal insufficiency | |
| HP:0001250 | Seizure | |
| HP:0002321 | Vertigo | |
| Very rare (<4-1%) | ||
| HP:0000509 | Conjunctivitis | |
Annotation source: 32310574[PMID]_27496039[PMID]_36312688[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/565782
- This record as JSON: /data/d/565782.json