Osteochondrosis of the metatarsal bone
Synonyms: Avascular necrosis of the metatarsal bone · Freiberg disease · Freiberg infraction
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- Adolescent, Adult
- Status
- active
A rare bone disease characterized by avascular necrosis of a metatarsal head, most commonly involving the second, but also the third or fourth, metatarsal. Patients may present with pain on weight-bearing, swelling, and tenderness. Radiological features include widening of the metatarsophalangeal joint space and flattening of the affected metatarsal head, at later stages metatarsal head sclerosis, cortical thickening, and intra-articular loose bodies. The condition can be bilateral in some cases and shows a significant predilection for females in the second or third decade of life.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Osteochondrosis of the metatarsal bone | Avascular necrosis of the metatarsal bone · Freiberg disease · Freiberg infraction |
| fr | Ostéochondrose du métatarse | Nécrose avasculaire du métatarse · Ostéochondrite du métatarse · Maladie de Freiberg |
| de | Osteochondrose des Mittelfußknochens | Avaskuläre Nekrose der Metatarsalköpfchen · Freiberg-Krankheit · Osteochondronekrose der Metatarsalköpfchen |
| es | Osteocondrosis de hueso metatarsiano | Enfermedad de Freiberg · Infracción de Freiberg · Necrosis avascular de hueso metatarsiano |
| it | Osteocondrosi del metatarso | Infrazione di Freiberg · Malattia di Freiberg · Necrosi avascolare del metatarso |
| nl | Osteochondrose van metatarsaal bot | Avasculaire necrose van metatarsaal bot · Infarct van Freiberg · Ziekte van Freiberg |
| pt | Osteocondrose do osso metatarso | |
| pl | Osteochondroza kości śródstopia | Choroba Freiberga |
| cs | Osteochondróza zánártní kosti | = en |
| uk | Остеохондроз плеснової кістки | Аваскулярний некроз плеснової кістки · Хвороба Фрейберга · Порушення Фрайберга |
| zh | 跖骨软骨病 | 跖骨无菌性坏死 |
| tr | Metatarsal kemiğin osteokondrozu | Freiberg hastalığı · Freiberg ihlali · Metatarsal kemiğin avasküler nekrozu |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | M92.7 | E | specific | validated |
| ICD-11 | FB82.1 | NTBT | index | validated |
| MONDO | 0023188 | E | validated | |
| MeSH | C535636 | E | validated | |
| UMLS | C0264099 | E | validated | |
| GARD | 2380 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:399319Osteochondrosis
rare systemic and rheumatological diseases; rare bone diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only | Validated | ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
19 annotations · validated 2021-06-11| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Frequent (79-30%) | ||
| HP:0010630 | Abnormality of metatarsal epiphysis | |
| HP:0040034 | Abnormality of the second metatarsal bone | |
| HP:0002829 | Arthralgia | |
| HP:0001369 | Arthritis | |
| HP:0100662 | Chondritis | |
| HP:0005194 | Flattened metatarsal heads | |
| HP:0025238 | Foot pain | |
| HP:0001288 | Gait disturbance | |
| HP:0001387 | Joint stiffness | |
| HP:0040188 | Osteochondrosis | |
| HP:0010741 | Pedal edema | |
| HP:0005187 | Progressive joint destruction | |
| HP:0100925 | Sclerosis of foot bone | |
| HP:0010219 | Structural foot deformity | |
| HP:0100039 | Thickened cortex of bones | |
| Occasional (29-5%) | ||
| HP:0010672 | Abnormality of the third metatarsal bone | |
| HP:0010885 | Avascular necrosis | |
| Very rare (<4-1%) | ||
| HP:0008089 | Abnormality of the fifth metatarsal bone | |
| HP:0040035 | Abnormality of the fourth metatarsal bone | |
Annotation source: 32653393[PMID]_30685014[PMID]_32917526[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/564003
- This record as JSON: /data/d/564003.json