Infection-related hemolytic uremic syndrome
Synonyms: Infection-related HUS
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- All ages
- Status
- active
A rare type of hemolytic uremic syndrome (HUS) characterized by the triad of hemolytic anemia due to generalized thrombotic microangiopathy, thrombocytopenia, and acute kidney injury, and most commonly occurring after acute gastroenteritis due to Shiga toxin-producing enterohemorrhagic <i>Escherichia coli</i> or <i>Shigella dysenteriae</i>. Other infectious causes of HUS include <i>Streptococcus pneumoniae</i>, HIV, <i>Mycoplasma pneumoniae</i>, Histoplasmosis, and Coxsackie virus.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Infection-related hemolytic uremic syndrome | Infection-related HUS |
| fr | Syndrome hémolytique et urémique dû à une infection | SHU dû à une infection |
| de | Infektions-assoziiertes hämolytisch-urämisches Syndrom | Infektion-bedingtes HUS |
| es | Síndrome hemolítico urémico asociado a infección | SHU asociado a infección |
| it | Sindrome emolitico-uremica correlata ad infezione | SEU correlata alle infezioni |
| nl | Infectie-gerelateerd hemolytisch-uremisch syndroom | Infectie-gerelateerd HUS |
| pt | Síndrome hemolítico-urémico infecção-relacionado | SHU infecção-relacionado |
| pl | Zespół hemolityczno-mocznicowy związany z infekcją | = en |
| cs | Hemolyticko-uremický syndrom související s infekcí | HUS související s infekcí |
| uk | Інфекційний гемолітико-уремічний синдром, повязаний з інфекцією | HUS, повязаний з інфекцією |
| zh | 感染性溶血性尿毒症综合征 | = en |
| tr | Enfeksiyon-ilişkili hemolitik üremik sendrom | Enfeksiyon-ilişkili HUS |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | D59.3 | NTBT | attributed | validated |
| ICD-11 | 3A21.Y | NTBT | index | validated |
| MONDO | 0034103 | E | validated | |
| UMLS | C5680165 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (2):
- ORPHA:544458Hemolytic uremic syndrome
rare renal diseases; rare transplant-related disorders - ORPHA:182047Rare acquired hemolytic anemia
rare hematological diseases
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only | Validated | ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
52 annotations · validated 2021-06-09| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0001919 | Acute kidney injury | |
| HP:0012378 | Fatigue | |
| HP:0001878 | Hemolytic anemia | |
| HP:0000980 | Pallor | |
| HP:0032169 | Severe infection | |
| HP:0001873 | Thrombocytopenia | |
| Frequent (79-30%) | ||
| HP:0032155 | Abdominal cramps | |
| HP:0002027 | Abdominal pain | |
| HP:0011115 | Abnormality of chemokine secretion | |
| HP:0011116 | Abnormality of interferon secretion | |
| HP:0000707 | Abnormality of the nervous system | |
| HP:0100282 | Acute colitis | |
| HP:0011037 | Decreased urine output | |
| HP:0002014 | Diarrhea | |
| HP:0001945 | Fever | |
| HP:0030783 | Increased circulating interleukin 6 concentration | |
| HP:0001974 | Increased total leukocyte count | |
| HP:0011947 | Respiratory tract infection | |
| Occasional (29-5%) | ||
| HP:0100519 | Anuria | |
| HP:0031864 | Bacteremia | |
| HP:0025085 | Bloody diarrhea | |
| HP:0002094 | Dyspnea | |
| HP:0000969 | Edema | |
| HP:0002153 | Hyperkalemia | |
| HP:0000822 | Hypertension | |
| HP:0100735 | Hypertensive crisis | |
| HP:0002901 | Hypocalcemia | |
| HP:0002902 | Hyponatremia | |
| HP:0001287 | Meningitis | |
| HP:0012819 | Myocarditis | |
| HP:0002018 | Nausea | |
| HP:0012593 | Nephrotic range proteinuria | |
| HP:0100520 | Oliguria | |
| HP:0001733 | Pancreatitis | |
| HP:0002102 | Pleuritis | |
| HP:0002090 | Pneumonia | |
| HP:0004372 | Reduced consciousness | |
| HP:0005208 | Secretory diarrhea | |
| HP:0031691 | Severe viral infection | |
| HP:0002013 | Vomiting | |
| Very rare (<4-1%) | ||
| HP:0030049 | Brain abscess | |
| HP:0100704 | Cerebral visual impairment | |
| HP:0001259 | Coma | |
| HP:0000819 | Diabetes mellitus | |
| HP:0005244 | Gastrointestinal infarctions | |
| HP:0007430 | Generalized edema | |
| HP:0001269 | Hemiparesis | |
| HP:0031368 | Intestinal perforation | |
| HP:0002576 | Intussusception | |
| HP:0011919 | Pleural empyema | |
| HP:0001250 | Seizure | |
| HP:0003095 | Septic arthritis | |
Run the differential on the 6 obligate / very frequent terms
Annotation source: 25593915[PMID]_27768015[PMID]_28242109[PMID]_31232894[PMID]_28711159[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/544482
- This record as JSON: /data/d/544482.json