Osteoradionecrosis of the mandible
Synonyms: MORN
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Status
- active
A rare radiation-induced disorder characterized by exposed irradiated bone that fails to heal over a period of three months without evidence of persisting or recurrent tumor. Patients present with pain, dysesthesia, dysgeusia, fetor oris, trismus, ulceration or necrosis of the mucosa with exposure of necrotic bone, and local suppuration. Complications include pathological fractures, formation of intra- or extra-oral fistulae, and infection. MRI shows cortical destruction, abnormal bone marrow signal, and irregular contrast enhancement.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Osteoradionecrosis of the mandible | MORN |
| fr | Ostéoradionécrose mandibulaire | |
| de | Osteoradionekrose der Mandibula | = en |
| es | Osteorradionecrosis de la mandíbula | = en |
| it | Osteoradionecrosi della mandibola | = en |
| nl | Osteoradionecrose van mandibula | MORN · Osteoradionecrose van onderkaak |
| pt | Osteoradionecrose da mandíbula | |
| pl | Martwica popromienna żuchwy | = en |
| cs | Osteoradionekróza mandibuly | = en |
| uk | Остеорадіонекроз нижньої щелепи | |
| zh | 下颌骨放射性骨坏死 | |
| tr | Mandibulanın osteoradiyonekrozu |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | K10.2 | NTBT | inclusion | not yet validated |
| ICD-11 | DA06.0 | NTBT | index | validated |
| MONDO | 0033839 | E | validated | |
| UMLS | C1290728 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (2):
- ORPHA:399158Osteonecrosis
rare systemic and rheumatological diseases; rare bone diseases - ORPHA:521132Radiation-induced disorder
rare disorders due to toxic effects
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
0 recordsNo prevalence record in this release.
HPO phenotypes
Orphanet has no HPO annotation for this code in this release.
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/521127
- This record as JSON: /data/d/521127.json