Ventilator-induced diaphragmatic dysfunction
Synonyms: VIDD
- Type
- Particular clinical situation in a disease or syndrome
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- All ages
- Status
- active
A rare respiratory disorder characterized by major reduction of diaphragmatic contractile force together with fiber atrophy in the diaphragm and other respiratory muscles as a consequence of invasive mechanical ventilation. Reduction of diaphragmatic contractile force may be observed even within hours after intubation. The condition can increase weaning time and affects weaning outcome, mortality, and long-term clinical outcomes.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Ventilator-induced diaphragmatic dysfunction | VIDD |
| fr | Dysfonction diaphragmatique induite par la ventilation mécanique | |
| de | Beatmungsinduzierter Zwerchfellschaden | VIDD · Ventilator-induzierter Zwerchfellschaden |
| es | Disfunción diafragmática inducida por la ventilación | DDIV |
| it | Disfunzione del diaframma indotta dalla ventilazione meccanica | |
| nl | Disfunctie van diafragma geïnduceerd door kunstmatige beademing | = en |
| pt | Disfunção diafragmática induzida pelo ventilador | |
| pl | Mechaniczna wentylacja-wywołanie dysfunkcji przepony | = en |
| cs | Dysfunkce bránice vyvolaná ventilátorem | = en |
| uk | Діафрагмальна дисфункція, зумовлена ШВЛ | = en |
| zh | 呼吸机诱发的膈肌功能障碍 | = en |
| tr | Ventilatör kaynaklı diyafram disfonksiyonu | = en |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | J95.8 | NTBT | attributed | validated |
| ICD-11 | NE8Y | NTBT | attributed | validated |
| UMLS | C5680083 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:101944Rare pulmonary disease
rare respiratory diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only | Validated | ORPHANET_28887062[PMID] |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
14 annotations · validated 2021-06-02| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0000775 | Abnormality of the diaphragm | |
| HP:0009113 | Diaphragmatic weakness | |
| HP:0025464 | Increased reactive oxygen species production | |
| HP:0005946 | Ventilator dependence with inability to wean | |
| Frequent (79-30%) | ||
| HP:0003457 | EMG abnormality | |
| HP:0012496 | Reduced maximal inspiratory pressure | |
| HP:0032169 | Severe infection | |
| Occasional (29-5%) | ||
| HP:0011458 | Abdominal symptom | |
| HP:0012416 | Hypercapnia | |
| HP:0000821 | Hypothyroidism | |
| HP:0032341 | Reduced forced vital capacity | |
| HP:0002747 | Respiratory insufficiency due to muscle weakness | |
| HP:0100806 | Sepsis | |
| Very rare (<4-1%) | ||
| HP:0006597 | Diaphragmatic paralysis | |
Run the differential on the 4 obligate / very frequent terms
Annotation source: 30453774[PMID]_28887062[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/505395
- This record as JSON: /data/d/505395.json