Chronic relapsing inflammatory optic neuritis
Synonyms: CRION
- Type
- Clinical subtype
- Group
- Subtype of disorder
- Inheritance
- Not applicable
- Status
- active
A rare inflammatory optic neuropathy characterized by severe and persistent pain followed by subacute visual loss, a relapsing-remitting course, and steroid-dependence. Involvement of both optic nerves is common and is usually sequential. Serum antibodies against aquaporin 4 are absent in most cases. Magnetic resonance imaging shows contrast enhancement of the acutely inflamed optic nerves.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Chronic relapsing inflammatory optic neuritis | CRION |
| fr | Névrite optique idiopathique récurrente chronique | CRION · Neuropathie optique inflammatoire isolée chronique récurrente · Neuropathie optique inflammatoire récidivante |
| de | Optikusneuritis, chronisch rezidivierende, inflammatorische | CRION · Optikusneuritis, chronisch rezidivierende, isolierte |
| es | Neuropatía óptica inflamatoria recurrente crónica | CRION · Neuritis óptica aislada recurrente crónica |
| it | Neuropatia ottica infiammatoria cronica recidivante | |
| nl | Chronische recidiverende inflammatoire opticusneuropathie | CRION · Chronische recidiverende inflammatoire optische neuropathie · Chronische terugkerende geïsoleerde opticusneuritis |
| pt | Chronic relapsing inflammatory optic neuropathy | CRION · Neuropatia óptica inflamatória recorrente crónica |
| pl | Przewlekła nawracająca zapalna neuropatia tarczy nerwu wzrokowego | Przewlekłe nawracające zapalenie nerwu wzrokowego |
| cs | Chronická návratná zánětlivá neuropatie optiku | CRION · Chronic recurrent isolated optic neuritis · Chronická recidivující izolovaná optická neuritida |
| uk | Хронічний рецидивуючий запальний неврит зорового нерва | = en |
| zh | 慢性复发性炎症性视神经病变 | 慢性复发性孤立性视神经炎 |
| tr | Kronik tekrarlı inflamatuar optik nöropati | CRION · Kronik tekrarlayan izole optik nörit |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | H46 | NTBT | attributed | validated |
| MONDO | 0044687 | E | validated | |
| UMLS | C5567234 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:499096Isolated optic neuritis
rare neurological diseases; rare ophthalmic disorders
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
0 recordsNo prevalence record in this release.
HPO phenotypes
Orphanet has no HPO annotation for this code in this release.
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/499085
- This record as JSON: /data/d/499085.json