Acquired methemoglobinemia
Synonyms: Drug-induced methemoglobinemia
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- All ages
- Status
- active
A rare hematologic disease characterized by increased levels of methemoglobin in the blood due to exposure to oxidizing agents like nitrates or nitrites, a variety of medications (most commonly local anesthetics), or aniline dyes, among others. Clinical manifestations include cyanosis, dizziness, headache, dyspnea, confusion, and coma. The severity of symptoms ranges from mild to life-threatening, depending on the percentage of methemoglobin.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Acquired methemoglobinemia | Drug-induced methemoglobinemia |
| fr | Méthémoglobinémie acquise | Méthémoglobinémie induite par les médicaments |
| de | Methämoglobinämie, erworbene | Methämoglobinämie, Medikamenten-induzierte |
| es | Metahemoglobinemia adquirida | Metahemoglobinemia inducida por fármacos |
| it | Metaemoglobinemia acquisita | |
| nl | Verworven methemoglobinemie | Medicatiegeïnduceerde methemoglobinemie |
| pt | Metahemoglobina adquirida | |
| pl | Methemoglobinemia nabyta | Methemoglobinemia indukowana lekami |
| cs | Získaná methemoglobinémie | Drug-induced methemoglobinemia · Methemoglobinémie vyvolaná léky |
| uk | Набута метгемоглобінемія | Медикаментозна метгемоглобінемія |
| zh | 获得性高铁血红蛋白血症 | 药物诱导的高铁血红蛋白血症 |
| tr | Edinsel methemoglobinemi | İlaç-ilişkili methemoglobinemi |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | D74.8 | NTBT | inclusion | validated |
| ICD-11 | 3A93 | E | specific | validated |
| MONDO | 0018740 | E | validated | |
| UMLS | C0271905 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (2):
- ORPHA:707993Methemoglobinemia-related cyanosis
rare hematological diseases - ORPHA:306640Rare intoxication due to medical products
rare disorders due to toxic effects
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
2 records| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Cases/families | 242 cases | Worldwide | Case(s) | Validated | 15342970[PMID]_19224791[PMID] | |
| Point prevalence | Unknown | — | Worldwide | Class only | Validated | ORPHANET_15342970[PMID]_19224791[PMID] |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
21 annotations · validated 2019-05-13| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0012119 | Methemoglobinemia | |
| Frequent (79-30%) | ||
| HP:0001941 | Acidosis | |
| HP:0000739 | Anxiety | |
| HP:0001289 | Confusion | |
| HP:0000961 | Cyanosis | |
| HP:0002094 | Dyspnea | |
| HP:0012378 | Fatigue | |
| HP:0002315 | Headache | |
| HP:0012418 | Hypoxemia | |
| HP:0001962 | Palpitations | |
| HP:0002321 | Vertigo | |
| HP:0002013 | Vomiting | |
| Occasional (29-5%) | ||
| HP:0002027 | Abdominal pain | |
| HP:0011675 | Arrhythmia | |
| HP:0001259 | Coma | |
| HP:0002329 | Drowsiness | |
| HP:0007185 | Loss of consciousness | |
| HP:0001279 | Syncope | |
| HP:0001649 | Tachycardia | |
| Very rare (<4-1%) | ||
| HP:0002098 | Respiratory distress | |
| HP:0001250 | Seizure | |
Run the differential on the 1 obligate / very frequent terms
Annotation source: 25637615[PMID]_27412886[PMID]_28667718[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/464453
- This record as JSON: /data/d/464453.json