Acute poisoning by drugs with membrane-stabilizing effect
- Type
- Particular clinical situation in a disease or syndrome
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- All ages
- Status
- active
A rare clinical situation characterized by acute, potentially life-threatening toxic effects of drugs acting on voltage-gated sodium or calcium channels, such as tricyclic antidepressants, anticonvulsants, local anesthetics and antiarrhythmics, some beta-blockers, and chloroquine. Clinical manifestations include abnormal ECG findings (intraventricular conduction block with widening of the QRS complex, T wave flattening, prolongation of the QT interval) and variable signs and symptoms depending on the drug, typically involving the cardiovascular and central nervous system, among others.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Acute poisoning by drugs with membrane-stabilizing effect | |
| fr | Intoxication aiguë par les médicaments avec effet stabilisant de membrane | |
| de | Akute Vergiftung durch Arzneimittel mit membranstabilisierender Wirkung | |
| es | Intoxicación aguda por fármacos con efecto estabilizador de membrana | |
| it | Intossicazione acuta da farmaci con effetto stabilizzante sulla membrana | |
| nl | Acute vergiftiging door geneesmiddelen met membraanstabiliserend effect | |
| pt | Intoxicação aguda por fármacos com efeito estabilizador de membranas | |
| pl | Ostre zatrucie lekami stabilizującymi błonę komórkową | |
| cs | Akutní otrava léky s membrány-stabilizujícím efektem | |
| uk | Гостре отруєння препаратами з мембраностабілізуючою дією | |
| zh | 具有膜稳定作用药物急性中毒 | |
| tr | Membran stabilize edici etkiye sahip ilaçlarla akut zehirlenme |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | X44 | NTBT | attributed | validated |
| ICD-11 | NE60 | NTBT | attributed | validated |
| MONDO | 0018548 | E | validated | |
| UMLS | C5681320 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:306640Rare intoxication due to medical products
rare disorders due to toxic effects
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only | Not yet validated | ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
Orphanet has no HPO annotation for this code in this release.
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/43119
- This record as JSON: /data/d/43119.json