Acute myeloid leukemia with t(9;11)(p22;q23)
Synonyms: AML with t(9;11)(p22;q23)
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Status
- active
A tumor of hematopoietic and lymphoid tissues characterized by the most common AML-causing MLL translocation, resulting in the MLL-MLLT3-fusion protein. It can occur either as a primary neoplasm or secondary to previous chemo-/radiation therapy. Clinical manifestations result from accumulation of malignant myeloid cells within the bone marrow, peripheral blood and other organs and include leukocytosis, anemia, thrombocytopenia, fever, bone pain, fatigue, pallor, easy bruising and frequent bleeding.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Acute myeloid leukemia with t(9;11)(p22;q23) | AML with t(9;11)(p22;q23) |
| fr | Leucémie myéloïde aiguë associée à t(9;11)(p22;q23) | |
| de | Akute myeloische Leukämie mit t(9;11)(p22;q23) | AML mit t(9;11)(p22;q23) |
| es | Leucemia mieloide aguda con t(9;11)(p22;q23) | LMA con t(9;11)(p22;q23) |
| it | Leucemia mieloide acuta con t(9;11)(p22;q23) | AML con t(9;11)(p22;q23) |
| nl | Acute myeloïde leukemie met t(9;11)(p22;q23) | AML met t(9;11)(p22;q23) |
| pt | Leucemia mieloide aguda com t(9;11)(p22;q23) | |
| pl | Ostra białaczka szpikowa z t(9;11)(p22;q23) | AML z t(9;11)(p22;q23) |
| cs | Akutní myeloidní leukémie s t(9;11)(p22;q23) | AML s t(9;11)(p22;q23) |
| uk | Гостра мієлоїдна лейкемія з t(9;11)(p22;q23) | AML з t(9;11)(p22;q23) |
| zh | 急性髓系白血病伴t(9;11)(p22;q23)变异 | AML伴t(9;11)(p22;q23) |
| tr | t(9; 11) (p22; q23) ile seyreden akut miyeloid lösemi | t(9;11)(p22;q23) ile seyreden AML |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | C92.0 | NTBT | attributed | validated |
| ICD-11 | 2A60.0 | NTBT | index | validated |
| MONDO | 0018434 | E | validated | |
| UMLS | C2919692 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:98277Acute myeloid leukemia with recurrent genetic anomaly
rare hematological diseases; rare neoplastic diseases; rare transplant-related disorders
No children.
Genes
2 direct| Gene | Association | Status | HGNC | Ensembl | OMIM | Locus | Name | Source of validation |
|---|---|---|---|---|---|---|---|---|
| KMT2A | Part of a fusion gene in | Assessed | HGNC:7132 | ENSG00000118058 | 159555 | 11q23.3 | lysine methyltransferase 2A | 19357394[PMID] |
| MLLT3 | Part of a fusion gene in | Assessed | HGNC:7136 | ENSG00000171843 | 159558 | 9p21.3 | MLLT3 super elongation complex subunit | 19357394[PMID] |
Prevalence and incidence
0 recordsNo prevalence record in this release.
HPO phenotypes
Orphanet has no HPO annotation for this code in this release.
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/402017
- This record as JSON: /data/d/402017.json