Secondary non-traumatic avascular necrosis
Synonyms: Secondary non-traumatic AVN · Secondary non-traumatic osteonecrosis
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- Adult
- Status
- active
A rare osteonecrosis disease characterized by death of bone cellular components secondary to an interruption of the subchondral blood supply, typically manifesting with unilateral or bilateral, unifocal or multifocal lesions usually located on the epiphysis, metaphysis and/or diaphysis of the femoral heads, knees, shoulders, ankles and/or wrists, leading to gradual onset of pain and progressive joint degeneration resulting in loss of function. Association with corticosteroid usage, alcoholism, hyperbaric events, radiation or cytotoxic agent exposure, hemoglobinopathies, and/or underlying autoimmune or metabolic disease, amongst others, has been observed.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Secondary non-traumatic avascular necrosis | Secondary non-traumatic AVN · Secondary non-traumatic osteonecrosis |
| fr | Nécrose avasculaire secondaire non traumatique | AVN secondaire non traumatique · Ostéonécrose secondaire non traumatique |
| de | Avaskuläre Nekrose, nicht-traumatische sekundäre | Sekundäre nicht-traumatische AVN · Sekundäre nicht-traumatische Osteonekrose |
| es | Necrosis avascular no traumática secundaria | AVN no traumática secundaria · Osteonecrosis no traumática secundaria |
| it | Necrosi secondaria non traumatica avascolare | AVN non traumatica secondaria |
| nl | Secundaire niet-traumatische avasculaire necrose | Secundaire niet-traumatische AVN · Secundaire niet-traumatische osteonecrose |
| pt | Necrose avascular secundária não-traumática | |
| pl | Wtórna martwica awaskularna niezwiązana z urazem | Wtórna AVN |
| cs | Sekundární netraumatická avaskulární nekróza | Sekundární netraumatická AVN |
| uk | Вторинний нетравматичний аваскулярний некроз | Вторинний нетравматичний АВН · Вторинний нетравматичний остеонекроз |
| zh | 继发性非缺血性坏死 | 继发性非创伤性骨坏死 |
| tr | Sekonder travmatik olmayan avasküler nekroz | Sekonder travmatik olmayan AVN · Sekonder travmatik olmayan osteonekroz |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | M87.1 | NTBT | attributed | validated |
| ICD-10 | M87.3 | NTBT | attributed | validated |
| ICD-11 | FB81.Y | NTBT | attributed | validated |
| MONDO | 0018376 | E | validated | |
| UMLS | C5192430 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:399169Secondary avascular necrosis
rare systemic and rheumatological diseases; rare bone diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only | Not yet validated | ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
13 annotations · validated 2019-10-24| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0010885 | Avascular necrosis | |
| Frequent (79-30%) | ||
| HP:0030955 | Alcoholism | |
| HP:0002960 | Autoimmunity | |
| HP:0002653 | Bone pain | |
| HP:0001376 | Limitation of joint mobility | |
| Occasional (29-5%) | ||
| HP:0003549 | Abnormality of connective tissue | |
| HP:0001288 | Gait disturbance | |
| HP:0031520 | Groin pain | |
| HP:0004377 | Hematological neoplasm | |
| HP:0002664 | Neoplasm | |
| HP:0001370 | Rheumatoid arthritis | |
| HP:0002725 | Systemic lupus erythematosus | |
| Very rare (<4-1%) | ||
| HP:0100724 | Hypercoagulability | |
Run the differential on the 1 obligate / very frequent terms
Annotation source: 19294340[PMID]_18524806[PMID]_9779852[PMID]_3768054[PMID]_8235665[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/399180
- This record as JSON: /data/d/399180.json