raremaprare-disease reference indexOrphadata 2026-06-23 · HPO 2026-09-01
ORPHA:398058

Squamous cell carcinoma of the penis

Synonyms: Penile squamous cell carcinoma

Type
Disease
Group
Disorder
Inheritance
Not applicable
Age of onset
Elderly
Status
active

A rare urogenital tumor characterized by origin from squamous epithelial cells of the penis, most commonly the glans or inner surface of the prepuce. Macroscopically, the tumors can appear either papillary or flat and ulcerating. Histological subtypes include usual squamous cell carcinoma as the most common type, as well as basaloid, warty, verrucous, papillary, and mixed carcinomas. Patients may initially be asymptomatic but present with itching, bleeding, discharge, foul odor, and pain, as the disease progresses. Regional lymph node involvement is common, while distant metastases occur only late in the disease. Risk factors include HPV infection, smoking, poor hygiene, and HIV infection. Neonatal circumcision is implicated as strongly protective.

1

Names in Orphadata languages

12 of 12 languages
LangNameSynonyms
enSquamous cell carcinoma of the penisPenile squamous cell carcinoma
frCarcinome épidermoïde de la vergeCarcinome épidermoïde du pénis
dePlattenepithelkarzinom des PenisSquamöses Karzinom des Penis
esCarcinoma de células escamosas del pene
itCarcinoma a cellule squamose del peneCarcinoma penieno a cellule squamose
nlPlaveiselcelcarcinoom van penisPeniel plaveiselcelcarcinoom
ptCarcinoma de células escamosas do pénis
plRak płaskonabłonkowy penisaRak płaskonabłonkowy prącia
csSkvamocelulární karcinom penisuPenilní skvamocelulární karcinom
ukПлоскоклітинний рак статевого членаПлоскоклітинний рак статевого члена
zh阴茎鳞状细胞癌阴茎鳞状细胞癌
trPenisin skuamöz hücreli karsinomuPenil skuamöz hücreli karsinom

Definition in:

2

Cross-references

qualifier = Orphanet mapping relation
SourceCodeQualifierICD relationValidation
ICD-10C60.0NTBTattributedvalidated
ICD-10C60.1NTBTattributedvalidated
ICD-10C60.2NTBTattributedvalidated
ICD-10C60.8NTBTattributedvalidated
ICD-10C60.9NTBTattributedvalidated
ICD-112C81.0Especificvalidated
MONDO0018352Evalidated
UMLSC0238348Evalidated
MedDRA10059631Evalidated

E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.

3

Classification

Preferential parent (Orphanet linearisation):

Parents in the classifications (1):

No children.

4

Genes

0 direct

Orphanet records no gene directly on this code.

5

Prevalence and incidence

24 records
TypeClassValueAreaQualificationValidationSource
Annual incidence1-9 / 1 000 0000.57 / 100 000EuropeValue and classValidated22119351[PMID]_RARECARE Surveillance of Rare Cancers in Europe 2003[OTHER]
Annual incidence1-9 / 1 000 0000.612 / 100 000NetherlandsValue and classValidatedRARECARE surveillance of rare cancers in Europe[OTHER]
Annual incidence1-9 / 1 000 0000.491 / 100 000AustriaValue and classValidatedRARECARE surveillance of rare cancers in Europe[OTHER]
Annual incidence1-9 / 1 000 0000.605 / 100 000BelgiumValue and classValidatedRARECARE surveillance of rare cancers in Europe[OTHER]
Annual incidence1-9 / 1 000 0000.516 / 100 000BulgariaValue and classValidatedRARECARE surveillance of rare cancers in Europe[OTHER]
Annual incidence1-9 / 1 000 0000.423 / 100 000CroatiaValue and classValidatedRARECARE surveillance of rare cancers in Europe[OTHER]
Annual incidence1-9 / 1 000 0000.684 / 100 000Czech RepublicValue and classValidatedRARECARE surveillance of rare cancers in Europe[OTHER]
Annual incidence1-9 / 1 000 0000.6 / 100 000EstoniaValue and classValidatedRARECARE surveillance of rare cancers in Europe[OTHER]
Annual incidence1-9 / 1 000 0000.426 / 100 000FinlandValue and classValidatedRARECARE surveillance of rare cancers in Europe[OTHER]
Annual incidence1-9 / 1 000 0000.638 / 100 000GermanyValue and classValidatedRARECARE surveillance of rare cancers in Europe[OTHER]
Annual incidence1-9 / 1 000 0000.682 / 100 000IcelandValue and classValidatedRARECARE surveillance of rare cancers in Europe[OTHER]
Annual incidence1-9 / 1 000 0000.475 / 100 000IrelandValue and classValidatedRARECARE surveillance of rare cancers in Europe[OTHER]
Annual incidence1-9 / 1 000 0000.606 / 100 000ItalyValue and classValidatedRARECARE surveillance of rare cancers in Europe[OTHER]
Annual incidence1-9 / 1 000 0000.552 / 100 000LatviaValue and classValidatedRARECARE surveillance of rare cancers in Europe[OTHER]
Annual incidence1-9 / 1 000 0000.517 / 100 000LithuaniaValue and classValidatedRARECARE surveillance of rare cancers in Europe[OTHER]
Annual incidence1-9 / 1 000 0000.628 / 100 000MaltaValue and classValidatedRARECARE surveillance of rare cancers in Europe[OTHER]
Annual incidence1-9 / 1 000 0000.744 / 100 000NorwayValue and classValidatedRARECARE surveillance of rare cancers in Europe[OTHER]
Annual incidence1-9 / 1 000 0000.396 / 100 000PolandValue and classValidatedRARECARE surveillance of rare cancers in Europe[OTHER]
Annual incidence1-9 / 1 000 0000.745 / 100 000PortugalValue and classValidatedRARECARE surveillance of rare cancers in Europe[OTHER]
Annual incidence1-9 / 1 000 0000.499 / 100 000SlovakiaValue and classValidatedRARECARE surveillance of rare cancers in Europe[OTHER]
Annual incidence1-9 / 1 000 0000.45 / 100 000SloveniaValue and classValidatedRARECARE surveillance of rare cancers in Europe[OTHER]
Annual incidence1-9 / 1 000 0000.791 / 100 000SpainValue and classValidatedRARECARE surveillance of rare cancers in Europe[OTHER]
Annual incidence1-9 / 1 000 0000.597 / 100 000SwitzerlandValue and classValidatedRARECARE surveillance of rare cancers in Europe[OTHER]
Annual incidence1-9 / 1 000 0000.691 / 100 000United KingdomValue and classValidatedRARECARE surveillance of rare cancers in Europe[OTHER]

Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.

6

HPO phenotypes

Orphanet has no HPO annotation for this code in this release.

7

Sources for this card