Off-periods in Parkinson disease not responding to oral treatment
- Type
- Particular clinical situation in a disease or syndrome
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- Adult, Elderly
- Status
- active
A rare clinical situation occurring in the context of Parkinson disease characterized by return or worsening of symptoms (including motor and/or non-motor symptoms) under antiparkinsonian therapy. Types of off-periods are Morning Off (experienced before the first dose of the day), Delayed On (occurring more frequently after the first dose of the day or after meals), Wearing Off (end-of-dose deterioration), Sudden Off (sudden transition from on to off), and Dose Failure.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Off-periods in Parkinson disease not responding to oral treatment | |
| fr | Périodes off de la maladie de Parkinson ne répondant pas aux traitements par voie orale | |
| de | Medikamentöse Off-Phase in der Parkinson-Krankheit | |
| es | Períodos 'off' en la enfermedad de Parkinson que no responden al tratamiento oral | |
| it | Periodi "off" nella malattia di Parkinson che non rispondono ai trattamenti per via orale | |
| nl | Off-periodes bij ziekte van Parkinson die niet reageren op orale behandeling | |
| pt | Períodos sem resposta à terapêutica oral na doença de Parkinson | |
| pl | Okresy wyłączeń w chorobie Parkinsona niereagujące na leczenie doustne | |
| cs | Off-periody u Parkinsonovy choroby neodpovídající na orální léčbu | |
| uk | Періоди погіршення симптомів при хворобі Паркінсона, які не піддаються пероральному лікуванню | |
| zh | 帕金森病口服治疗无效的间歇期 | |
| tr | Parkinson hastalığında oral tedaviye yanıt vermeyen dönemler |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | G20 | NTBT | attributed | validated |
| UMLS | C5681154 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:68402Rare parkinsonian disorder
rare neurological diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | 1-9 / 100 000 | 4.15 / 100 000 | Europe | Value and class | Validated | European Medicines Agency 2004[OTHER] |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
Orphanet has no HPO annotation for this code in this release.
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/391655
- This record as JSON: /data/d/391655.json