Adiposis dolorosa
Synonyms: Adiposalgia · Adipose tissue rheumatism · Dercum disease · Lipomatosis dolorosa
- Type
- Disease
- Group
- Disorder
- Inheritance
- Autosomal dominant, Not applicable
- Age of onset
- Adult
- Status
- active
A rare disorder of subcutaneous tissue characterized by the development of painful, adipose tissue with multiple subcutaneous lipomas, in association with overweight or obesity.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Adiposis dolorosa | Adiposalgia · Adipose tissue rheumatism · Dercum disease · Lipomatosis dolorosa |
| fr | Adipose douloureuse | Lipomatose symétrique douloureuse · Maladie de Dercum · Neurolipomatose douloureuse de Dercum |
| de | Adipositas dolorosa | Adiposalgie · Dercum-Krankheit · Fettgewebs-Rheumatismus · Lipomatosis dolorosa |
| es | Adiposis dolorosa | Adiposalgia · Enfermedad de Dercum · Lipomatosis dolorosa · Reumatismo del tejido adiposo |
| it | Adiposi dolorosa | Malattia di Dercum · Neurolipomatosi |
| nl | Adiposis dolorosa | Adiposalgie · Lipomatosis dolorosa · Vetweefselreuma · Ziekte van Dercum |
| pt | Adipose dolorosa | Doença de Dercum · Neurolipomatose |
| pl | Tłuszczakowatość bolesna | Choroba Dercuma · Neurolipomatoza · Lipomatoza bolesna · Reumatyzm tkanki tłuszczowej |
| cs | Adipositas dolorosa | Adiposalgie · Dercumova nemoc · Lipomatosis dolorosa · Neurolipomatóza · Revmatismus tukové tkáně |
| uk | Болючи ліпоми | Адипосальгія · Ревматизм жирової тканини · Хвороба Деркума · Червоний плоский лишай |
| zh | 痛性肥胖病 | 脂肪组织风湿病 |
| tr | Adipoz dolorosa | Adiposalji · Dercum hastalığı · Lipomatoz dolorosa · Yağ dokusu romatizması |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| OMIM | 103200 | E | validated | |
| ICD-10 | E88.2 | NTBT | attributed | validated |
| ICD-11 | EF02.1 | NTBT | index | validated |
| MONDO | 0007070 | E | validated | |
| MeSH | D000274 | E | validated | |
| UMLS | C0001529 | E | validated | |
| GARD | 5750 | E | validated | |
| MedDRA | 10001294 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:79382Subcutaneous tissue disease
rare skin diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only | Not yet validated | ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
39 annotations · validated 2024-06-13| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0000739 | Anxiety | |
| HP:0002829 | Arthralgia | |
| HP:0000716 | Depression | |
| HP:0012378 | Fatigue | |
| HP:0001513 | Obesity | |
| HP:0001482 | Subcutaneous nodule | |
| Frequent (79-30%) | ||
| HP:0003270 | Abdominal distention | |
| HP:0002027 | Abdominal pain | |
| HP:0003119 | Abnormal circulating lipid concentration | |
| HP:0025406 | Asthenia | |
| HP:0012532 | Chronic pain | |
| HP:0011227 | Elevated circulating C-reactive protein concentration | |
| HP:0003565 | Elevated erythrocyte sedimentation rate | |
| HP:0031905 | Increased total hemolytic complement activity | |
| HP:0025502 | Overweight | |
| HP:0007596 | Painful subcutaneous lipomas | |
| HP:0002215 | Sparse axillary hair | |
| HP:0002225 | Sparse pubic hair | |
| HP:0001031 | Subcutaneous lipoma | |
| Occasional (29-5%) | ||
| HP:0001369 | Arthritis | |
| HP:0002960 | Autoimmunity | |
| HP:0000978 | Bruising susceptibility | |
| HP:0002019 | Constipation | |
| HP:0002376 | Developmental regression | |
| HP:0000819 | Diabetes mellitus | |
| HP:0002014 | Diarrhea | |
| HP:0000958 | Dry skin | |
| HP:0002315 | Headache | |
| HP:0000822 | Hypertension | |
| HP:0000821 | Hypothyroidism | |
| HP:0034265 | Mastalgia | |
| HP:0002354 | Memory impairment | |
| HP:0003401 | Paresthesia | |
| HP:0009830 | Peripheral neuropathy | |
| HP:0001581 | Recurrent skin infections | |
| HP:0001250 | Seizure | |
| HP:0002360 | Sleep abnormality | |
| HP:0100585 | Telangiectasia of the skin | |
| HP:0000217 | Xerostomia | |
Run the differential on the 6 obligate / very frequent terms
Annotation source: 31844341[PMID]_33800991[PMID]_38084160[PMID]_29939644[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/36397
- This record as JSON: /data/d/36397.json