Non-seminomatous germ cell tumor of testis
Synonyms: Non-dysgerminomatous germ cell tumor of testis · Testicular non seminomatous germ cell tumor · Testicular non-dysgerminomatous germ cell tumor
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- Adult
- Status
- active
A form of testicular germ cell tumor occurring in the third decade of life with a usually painless unilateral mass in the scrotum or, in some cases, with gynaecomastia and/or back and flack pain. The clinical course is more aggressive than testicular seminomatous germ cell tumors with rapid involvement of blood vessels and a poorer prognosis. Histologically, the tumour can be either undifferentiated (embryonal carcinoma), differentiated (teratoma, yolk sac tumor, choriocarcinoma), or can consist of a mixture of seminomatous and nonseminomatous components.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Non-seminomatous germ cell tumor of testis | Non-dysgerminomatous germ cell tumor of testis · Testicular non seminomatous germ cell tumor · Testicular non-dysgerminomatous germ cell tumor |
| fr | Tumeur germinale non séminomateuse des testicules | Tumeur germinale non dysgerminomateuse des testicules · Tumeur testiculaire germinale non dysgerminomateuse · Tumeur testiculaire germinale non-séminomateuse |
| de | Testikulärer Keimzelltumor, nicht-seminomatöser | Nicht-seminomatöser Keimzelltumor des Hodens |
| es | Tumor testicular germinal no seminomatoso | Tumor germinal no disgerminomatoso de los testículos · Tumor germinal no seminomatoso de los testículos · Tumor testicular germinal no disgerminomatoso |
| it | Tumore testicolare non seminomatoso delle cellule germinali | Tumore non disgerminomatoso delle cellule germinali del testicolo · Tumore non seminomatoso delle cellule germinali del testicolo · Tumore testicolare non disgerminomatoso delle cellule germinali |
| nl | Testiculaire niet-seminomateuze kiemceltumor | Niet-dysgerminomateuze kiemceltumor van de testis · Niet-seminomateuze kiemceltumor van de testis · Testiculaire niet-dysgerminomateuze kiemceltumor |
| pt | Tumor testicular de células germinativas não seminais | |
| pl | Nienasieniakowy zarodkowy nowotwór jądra | Guz jąder inny niż dysgerminoma |
| cs | Non-seminomový germinální nádor varlat | = en |
| uk | Несеміноматозна герміногенна пухлина яєчка | Недисгерміноматозна герміногенна пухлина яєчка · Несеміноматозна герміногенна пухлина яєчка · Недисгерміноматозна герміногенна пухлина яєчка |
| zh | 非精原细胞睾丸生殖细胞瘤 | 睾丸非无性细胞性生殖细胞肿瘤 |
| tr | Testisin seminomatöz olmayan germ hücreli tümörü | Testiküler seminomatöz olmayan germ hücreli tümör · Testisin disgerminomatöz olmayan germ hücreli tümörü · Testiküler diserminomatöz olmayan germ hücreli tümör |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| OMIM | 273300 | NTBT | validated | |
| ICD-10 | C62.1 | NTBT | attributed | validated |
| MONDO | 0006447 | E | validated | |
| UMLS | C2057625 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:363504Germ cell tumor of testis
rare urogenital diseases; rare neoplastic diseases; rare transplant-related disorders
No children.
Genes
2 direct| Gene | Association | Status | HGNC | Ensembl | OMIM | Locus | Name | Source of validation |
|---|---|---|---|---|---|---|---|---|
| KITLG | Major susceptibility factor in | Assessed | HGNC:6343 | ENSG00000049130 | 184745 | 12q21.32 | KIT ligand | 19483682[PMID]_20228134[PMID]_23640991[PMID] |
| SPRY4 | Major susceptibility factor in | Assessed | HGNC:15533 | ENSG00000187678 | 607984 | 5q31.3 | sprouty RTK signaling antagonist 4 | 19483682[PMID]_23640991[PMID] |
Prevalence and incidence
2 records| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Annual incidence | 1-9 / 100 000 | 1.21 / 100 000 | Europe | Value and class | Validated | 22033323[PMID]_RARECARE surveillance of rare cancers in Europe[OTHER] |
| Lifetime Prevalence | 1-5 / 10 000 | 33.53 / 100 000 | Europe | Value and class | Validated | 22033323[PMID]_RARECARE surveillance of rare cancers in Europe[OTHER] |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
Orphanet has no HPO annotation for this code in this release.
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/363494
- This record as JSON: /data/d/363494.json