Staphylococcal necrotizing pneumonia
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- Childhood
- Status
- active
Staphylococcal necrotizing pneumonia is a rare, bacterial, pulmonary infectious disease, caused by a Panton-Valentine leukocidin-producing Staphylococcus aureus strain, characterized by severe respiratory failure, extensive, rapidly progressing pneumonia and hemorrhagic lung necrosis. Patients typically present with influenza-like symptoms, such as fever, cough, and chest pain, as well as hemoptysis, hypotension, leukopenia, and severe respiratory symptoms that rapidly evolve to acute respiratory distress syndrome and septic shock. High mortality is associated.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Staphylococcal necrotizing pneumonia | |
| fr | Pneumonie nécrosante staphylococcique | |
| de | Pneumonie, nekrotisierende, Staphylokokken-induzierte | |
| es | Neumonía necrotizante estafilocócica | |
| it | Polmonite necrotizzante da stafilococco | |
| nl | Door stafylokokken veroorzaakte necrotiserende pneumonie | |
| pt | Pneumonia necrotizante por estafilococos | |
| pl | Gronkowcowe martwicze zapalenie płuc | |
| cs | Stafylokoková nekrotizující pneumonie | |
| uk | Стафілококова некротична пневмонія | |
| zh | 葡萄球菌坏死性肺炎 | |
| tr | Stafilokokal nekrotizan pnömoni |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | J15.2 | NTBT | attributed | validated |
| ICD-11 | CA40.06 | NTBT | attributed | validated |
| MONDO | 0018183 | E | validated | |
| UMLS | C4706659 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (2):
- ORPHA:101944Rare pulmonary disease
rare respiratory diseases - ORPHA:300579Staphylococcal toxemia
rare infectious diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only | Not yet validated | ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
38 annotations · validated 2020-04-21| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0012735 | Cough | |
| HP:0002094 | Dyspnea | |
| HP:0003565 | Elevated erythrocyte sedimentation rate | |
| HP:0001945 | Fever | |
| HP:0001974 | Increased total leukocyte count | |
| HP:0002090 | Pneumonia | |
| HP:0002098 | Respiratory distress | |
| HP:0032169 | Severe infection | |
| HP:0002789 | Tachypnea | |
| Frequent (79-30%) | ||
| HP:0011949 | Acute infectious pneumonia | |
| HP:0031864 | Bacteremia | |
| HP:0100749 | Chest pain | |
| HP:0011227 | Elevated circulating C-reactive protein concentration | |
| HP:0002615 | Hypotension | |
| HP:0012418 | Hypoxemia | |
| HP:0032308 | Increased circulating procalcitonin concentration | |
| HP:0011897 | Neutrophilia | |
| HP:0031246 | Nonproductive cough | |
| HP:0032177 | Parenchymal consolidation | |
| HP:0002202 | Pleural effusion | |
| HP:0011919 | Pleural empyema | |
| HP:0002878 | Respiratory failure | |
| Occasional (29-5%) | ||
| HP:0032016 | Abnormal sputum | |
| HP:0001289 | Confusion | |
| HP:0100758 | Gangrene | |
| HP:0002105 | Hemoptysis | |
| HP:0002721 | Immunodeficiency | |
| HP:0001254 | Lethargy | |
| HP:0001882 | Leukopenia | |
| HP:0025439 | Pharyngitis | |
| HP:0002107 | Pneumothorax | |
| HP:0002113 | Pulmonary infiltrates | |
| HP:0025419 | Pulmonary pneumatocele | |
| HP:0100806 | Sepsis | |
| HP:0025144 | Shivering | |
| HP:0031273 | Shock | |
| Very rare (<4-1%) | ||
| HP:0030955 | Alcoholism | |
| HP:0000819 | Diabetes mellitus | |
Run the differential on the 9 obligate / very frequent terms
Annotation source: 28192581[PMID]_26785088[PMID]_24980464[PMID]_22388585[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/36238
- This record as JSON: /data/d/36238.json