Severe disseminated cytomegalovirus infection in immunocompetent patients
Synonyms: Severe disseminated CMV infection in immunocompetent patients
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- All ages
- Status
- active
A rare viral disease characterized by fulminant cytomegalovirus infection with multiple organ involvement including the brain, lung, liver, and/or heart, among others, and marked constitutional symptoms in immunocompetent patients. The condition is associated with a high case fatality rate.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Severe disseminated cytomegalovirus infection in immunocompetent patients | Severe disseminated CMV infection in immunocompetent patients |
| fr | Infection disséminée sévère à cytomégalovirus chez les patients immunocompétents | Infection disséminée sévère à CMV chez les patients immunocompétents |
| de | Schwere disseminierte Zytomegalievirus-Infektion bei immunkompetenten Patienten | Schwere disseminierte CMV-Infektion bei immunkompetenten Patienten |
| es | Infección diseminada por citomegalovirus grave en pacientes inmunocompetentes | Infección diseminada por CMV grave en pacientes inmunocompetentes |
| it | Infezione grave disseminata da citomegalovirus nei pazienti immunocompetenti | Infezione grave disseminata da CMV nei pazienti immunocompetenti |
| nl | Ernstige gedissemineerde infectie door cytomegalovirus bij immuuncompetente patiënten | Ernstige gedissemineerde CMV-infectie bij immuuncompetente patiënten |
| pt | Infeção disseminada grave por citomegalovirus em doentes sem imunodeficiência | Infeção disseminada grave por CMV em doentes sem imunodeficiência |
| pl | Idiopatyczna rosiane zakażenie cytomegalowirusem | Ciężkie rozsiane zakażenie cytomegalowirusem u pacjentów immunokompetentnych |
| cs | Těžká diseminovaná cytomegalovirová infekce u imunokompetentních pacientů | Idiopatická diseminovaná CMV infekce · Idiopatická diseminovaná cytomegalovirová infekce |
| uk | Тяжка дисемінована цитомегаловірусна інфекція в імунокомпетентних пацієнтів | Тяжка дисемінована ЦМВ-інфекція в імунокомпетентних пацієнтів |
| zh | 特发性播散性巨细胞病毒感染 | 特发性播散性巨细胞病毒感染 |
| tr | İdiyopatik yaygın sitomegalovirüs enfeksiyonu | İdiyopatik yaygın CMV enfeksiyonu |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | B25.8 | NTBT | attributed | validated |
| ICD-11 | 1D82.Y | NTBT | attributed | validated |
| UMLS | C5680152 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:163585Rare viral disease
rare infectious diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only | Not yet validated | ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
29 annotations · validated 2024-11-25| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0002583 | Colitis | |
| HP:0033431 | Cytomegalovirus colitis | |
| Frequent (79-30%) | ||
| HP:0002027 | Abdominal pain | |
| HP:0002039 | Anorexia | |
| HP:0430087 | Anti-cytomegalovirus antibody positivity | |
| HP:0001945 | Fever | |
| HP:0012115 | Hepatitis | |
| HP:0006515 | Interstitial pneumonitis | |
| HP:0001287 | Meningitis | |
| HP:0012486 | Myelitis | |
| HP:0002017 | Nausea and vomiting | |
| HP:0002090 | Pneumonia | |
| HP:0032118 | Retinitis | |
| HP:0000554 | Uveitis | |
| HP:0033993 | Viral encephalitis | |
| HP:0001824 | Weight loss | |
| Occasional (29-5%) | ||
| HP:0025143 | Chills | |
| HP:0001289 | Confusion | |
| HP:0033117 | Duodenitis | |
| HP:0012378 | Fatigue | |
| HP:0001878 | Hemolytic anemia | |
| HP:0003326 | Myalgia | |
| HP:0001733 | Pancreatitis | |
| HP:0000979 | Purpura | |
| HP:0000988 | Skin rash | |
| HP:0012223 | Splenic rupture | |
| HP:0001873 | Thrombocytopenia | |
| HP:0004936 | Venous thrombosis | |
| HP:0000572 | Visual loss | |
Run the differential on the 2 obligate / very frequent terms
Annotation source: 18371229[PMID]_25390262[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/35062
- This record as JSON: /data/d/35062.json