raremaprare-disease reference indexOrphadata 2026-06-23 · HPO 2026-09-01
ORPHA:3392

Tularemia

Type
Disease
Group
Disorder
Inheritance
Not applicable
Age of onset
All ages
Status
active

A rare bacterial infectious disease caused by <i>Francisella tularensis</i> and characterized by six major clinical presentations: ulceroglandular, glandular, oropharyngeal, oculoglandular, pneumonic, or typhoidal, depending on the route of infection. Early flu-like symptoms are common to all forms and are accompanied/followed by either a skin inoculation ulcer with localized lymphadenopathy; isolated lymphadenopathy; chronic pharyngitis with cervical lymphadenopathy; conjunctivitis with localized lymphadenopathy; lung involvement; severe systemic disease with neurological symptoms.

1

Names in Orphadata languages

12 of 12 languages
LangNameSynonyms
enTularemia
frTularémie
deTularämie
esTularemia
itTularemia
nlTularemie
ptTularemia
plTularemia
csTularémie
ukТуляремія
zh土拉杆菌病
trTularemi

Definition in:

2

Cross-references

qualifier = Orphanet mapping relation
SourceCodeQualifierICD relationValidation
ICD-10A21.0BTNTspecificvalidated
ICD-10A21.1BTNTspecificvalidated
ICD-10A21.2BTNTspecificvalidated
ICD-10A21.3BTNTspecificvalidated
ICD-10A21.7BTNTspecificvalidated
ICD-10A21.8BTNTspecificvalidated
ICD-10A21.9BTNTspecificvalidated
ICD-111B94Especificvalidated
ICD-111B94.0BTNTspecificvalidated
ICD-111B94.YBTNTattributedvalidated
MONDO0018077Evalidated
MeSHD014406Evalidated
UMLSC0041351Evalidated
GARD396Evalidated
MedDRA10045146Evalidated

E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.

3

Classification

Preferential parent (Orphanet linearisation):

Parents in the classifications (1):

No children.

4

Genes

0 direct

Orphanet records no gene directly on this code.

5

Prevalence and incidence

26 records
TypeClassValueAreaQualificationValidationSource
Annual incidence<1 / 1 000 000—United KingdomClass onlyValidated26738841[PMID]
Annual incidence<1 / 1 000 000—NetherlandsClass onlyValidated26738841[PMID]
Annual incidence1-9 / 100 0004 / 100 000SwedenValue and classValidated26738841[PMID]
Annual incidence1-9 / 100 0001.27 / 100 000Czech RepublicValue and classValidated26738841[PMID]
Annual incidence1-9 / 100 0009.1 / 100 000FinlandValue and classValidated26738841[PMID]
Annual incidence1-9 / 1 000 0000.1 / 100 000AustriaValue and classValidated26738841[PMID]
Annual incidence<1 / 1 000 0000.005 / 100 000BelgiumValue and classValidated26738841[PMID]
Annual incidence<1 / 1 000 0000.05 / 100 000DenmarkValue and classValidated26738841[PMID]
Annual incidence1-9 / 1 000 0000.3 / 100 000CroatiaValue and classValidated26738841[PMID]
Annual incidence1-9 / 1 000 0000.6 / 100 000BulgariaValue and classValidated26738841[PMID]
Annual incidence<1 / 1 000 0000.075 / 100 000EstoniaValue and classValidated26738841[PMID]
Annual incidence<1 / 1 000 0000.08 / 100 000FranceValue and classValidated26738841[PMID]
Annual incidence<1 / 1 000 0000.02 / 100 000GermanyValue and classValidated26738841[PMID]
Annual incidence<1 / 1 000 0000.035 / 100 000ItalyValue and classValidated26738841[PMID]
Annual incidence1-9 / 1 000 0000.145 / 100 000LatviaValue and classValidated26738841[PMID]
Annual incidence<1 / 1 000 0000.07 / 100 000LithuaniaValue and classValidated26738841[PMID]
Annual incidence<1 / 1 000 0000.01 / 100 000PolandValue and classValidated26738841[PMID]
Annual incidence<1 / 1 000 0000.01 / 100 000RomaniaValue and classValidated26738841[PMID]
Annual incidence<1 / 1 000 0000.01 / 100 000SloveniaValue and classValidated26738841[PMID]
Annual incidence1-9 / 1 000 0000.25 / 100 000SwitzerlandValue and classValidated26738841[PMID]
Annual incidence1-9 / 1 000 0000.75 / 100 000SpainValue and classValidated26738841[PMID]
Annual incidence1-9 / 100 0001.83 / 100 000NorwayValue and classValidated26738841[PMID]
Annual incidence1-9 / 1 000 0000.2 / 100 000EuropeValue and classValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Point prevalence1-9 / 100 0002 / 100 000EuropeValue and classValidatedEuropean Medicines Agency 2015[OTHER]
Annual incidence1-9 / 1 000 0000.5 / 100 000HungaryValue and classValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]
Annual incidence1-9 / 1 000 0000.1 / 100 000SlovakiaValue and classValidatedEuropean Centre for Disease prevention and Control 2013-2017[OTHER]

Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.

6

HPO phenotypes

38 annotations · validated 2020-11-24
HPOTerm (as annotated by Orphanet)Diagnostic
Frequent (79-30%)
HP:0002829Arthralgia
HP:0025406Asthenia
HP:0025143Chills
HP:0001945Fever
HP:0002315Headache
HP:0010702Increased circulating immunoglobulin concentration
HP:0001974Increased total leukocyte count
HP:0003326Myalgia
HP:0002090Pneumonia
HP:0001649Tachycardia
Occasional (29-5%)
HP:0031983Abnormal pulmonary thoracic imaging finding
HP:0001903Anemia
HP:0025289Cervical lymphadenopathy
HP:0012735Cough
HP:0011355Localized skin lesion
HP:0002716Lymphadenopathy
HP:0030833Neck pain
HP:0000155Oral ulcer
HP:0025439Pharyngitis
HP:0002202Pleural effusion
HP:0002113Pulmonary infiltrates
HP:0002098Respiratory distress
HP:0000988Skin rash
HP:0001873Thrombocytopenia
Very rare (<4-1%)
HP:3000033Abnormality of nasopharyngeal adenoids
HP:0000707Abnormality of the nervous system
HP:0000708Atypical behavior
HP:0030049Brain abscess
HP:0001289Confusion
HP:0030953Conjunctival hyperemia
HP:0000509Conjunctivitis
HP:0031292Cutaneous abscess
HP:0012219Erythema nodosum
HP:0100533Inflammatory abnormality of the eye
HP:0100721Mediastinal lymphadenopathy
HP:0001287Meningitis
HP:0200026Ocular pain
HP:0000388Otitis media

Annotation source: 22911645[PMID]_26738841[PMID]

7

Sources for this card