Lead poisoning
Synonyms: Lead intoxication · Plumbism · Saturnism
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- All ages
- Status
- active
Lead poisoning is defined as acute or chronic exposure to lead resulting in lead accumulation (blood lead concentration (BLC) >5 ug/dL) that can affect every organ system in the body and to which children are more susceptible. Clinical manifestations depend on the amount and duration of exposure and include abdominal pain, colic, constipation, lead line on gingival tissue, arthralgia, myalgia, peripheral neuropathy, fatigue, irritability, anemia, chronic nephropathy and hypertension. In children, even low levels of exposure (BLC <5 ug/dL) is reported to lead to irreversible effects such as loss of cognition, shortening of attention span, alteration of behavior, dyslexia, attention deficit disorder, hypertension, renal impairment, immunotoxicity and toxicity to the reproductive organs.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Lead poisoning | Lead intoxication · Plumbism · Saturnism |
| fr | Intoxication au plomb | Saturnisme |
| de | Bleivergiftung | Blei-Intoxikation · Saturnismus |
| es | Intoxicación por plomo | Envenenamiento por plomo · Plumbismo · Saturnismo |
| it | Avvelenamento da piombo | Intossicazione da piombo · Saturnismo |
| nl | Loodvergiftiging | Loodintoxicatie · Plumbisme · Saturnisme |
| pt | Intoxicação por chumbo | |
| pl | Zatrucie ołowiem | Intoksykacja ołowiem · Ołowica · Saturnizm |
| cs | Otrava olovem | Intoxikace olovem · Plumbismus · Saturnismus |
| uk | Отруєння свинцем | Свинцева інтоксикація · Плюмбізм · Сатурнізм |
| zh | 铅中毒 | = en |
| tr | Kurşun zehirlenmesi | Plumbizm · Satürnizm · Kurşun zehirlenmesi |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | T56.0 | E | specific | validated |
| ICD-11 | NE61 | NTBT | index | validated |
| MONDO | 0018019 | E | validated | |
| MeSH | D007855 | E | validated | |
| UMLS | C0023176 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:556508Rare disorder due to poisoning
rare disorders due to toxic effects
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
2 records| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | 1-9 / 100 000 | 2.3 / 100 000 | Europe | Value and class | Validated | European Medicines Agency 2013[OTHER] |
| Point prevalence | 1-9 / 1 000 000 | 0.68 / 100 000 | France | Value and class | Validated | OTHERitut de Veille Sanitaire 2010[OTHER]_ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
62 annotations · validated 2020-03-04| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Frequent (79-30%) | ||
| HP:0003270 | Abdominal distention | |
| HP:0002027 | Abdominal pain | |
| HP:0002039 | Anorexia | |
| HP:0002019 | Constipation | |
| HP:0012378 | Fatigue | |
| HP:0000822 | Hypertension | |
| HP:0002018 | Nausea | |
| HP:0002013 | Vomiting | |
| Occasional (29-5%) | ||
| HP:0032155 | Abdominal cramps | |
| HP:0002795 | Abnormal respiratory system physiology | |
| HP:0002715 | Abnormality of the immune system | |
| HP:0100511 | Abnormality of vitamin D metabolism | |
| HP:0001903 | Anemia | |
| HP:0007018 | Attention deficit hyperactivity disorder | |
| HP:0000708 | Atypical behavior | |
| HP:0100543 | Cognitive impairment | |
| HP:0000684 | Delayed eruption of teeth | |
| HP:0000716 | Depression | |
| HP:0002460 | Distal muscle weakness | |
| HP:0002315 | Headache | |
| HP:0005560 | Imbalanced hemoglobin synthesis | |
| HP:0031058 | Impairment of activities of daily living | |
| HP:0100785 | Insomnia | |
| HP:0100512 | Low levels of vitamin D | |
| HP:0002354 | Memory impairment | |
| HP:0007010 | Poor fine motor coordination | |
| HP:0007015 | Poor gross motor coordination | |
| HP:0100602 | Preeclampsia | |
| HP:0001622 | Premature birth | |
| HP:0000124 | Renal tubular dysfunction | |
| HP:0000988 | Skin rash | |
| HP:0001518 | Small for gestational age | |
| HP:0001328 | Specific learning disability | |
| HP:0005268 | Spontaneous abortion | |
| Very rare (<4-1%) | ||
| HP:0002843 | Abnormal T cell morphology | |
| HP:0012864 | Abnormal sperm morphology | |
| HP:0005368 | Abnormality of humoral immunity | |
| HP:0002270 | Abnormality of the autonomic nervous system | |
| HP:0000140 | Abnormality of the menstrual cycle | |
| HP:0002099 | Asthma | |
| HP:0012622 | Chronic kidney disease | |
| HP:0001259 | Coma | |
| HP:0004437 | Cranial hyperostosis | |
| HP:0003233 | Decreased HDL cholesterol concentration | |
| HP:0031429 | Decreased circulating osteocalcin level | |
| HP:0030018 | Decreased female libido | |
| HP:0040306 | Decreased male libido | |
| HP:0000823 | Delayed puberty | |
| HP:0002750 | Delayed skeletal maturation | |
| HP:0001298 | Encephalopathy | |
| HP:0003141 | Increased LDL cholesterol concentration | |
| HP:0003212 | Increased circulating IgE concentration | |
| HP:0000789 | Infertility | |
| HP:0001249 | Intellectual disability | |
| HP:0007178 | Motor polyneuropathy | |
| HP:0000798 | Oligozoospermia | |
| HP:0009830 | Peripheral neuropathy | |
| HP:0012760 | Reduced social responsiveness | |
| HP:0012207 | Reduced sperm motility | |
| HP:0001250 | Seizure | |
| HP:0003474 | Somatic sensory dysfunction | |
| HP:0001970 | Tubulointerstitial nephritis | |
Annotation source: 27902665[PMID]_30303719[PMID]_29214886[PMID]_27661040[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/330015
- This record as JSON: /data/d/330015.json