Autoerythrocyte sensitization syndrome
Synonyms: GDS · Gardner-Diamond syndrome · Painful bruising syndrome · Psychogenic purpura
- Type
- Disease
- Group
- Disorder
- Inheritance
- Unknown
- Age of onset
- Adult
- Status
- active
A rare autoimmune disease with skin involvement characterized by recurrent episodes with isolated or multiple painful edematous inflammatory skin lesions progressing to ecchymoses within 24 hours, due to autosensitization to a stromal component of the patient's own erythrocytes. The development of the lesions is usually preceded by emotional or physical stress, followed by a prodromal stage with fatigue or malaise. Lower limbs and trunk are the most frequently involved sites. Accompanying features may include fever, arthralgia, myalgia, headache, gastrointestinal problems, or hematuria and epistaxis, among others. The disease occurs predominantly in women.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Autoerythrocyte sensitization syndrome | GDS · Gardner-Diamond syndrome · Painful bruising syndrome · Psychogenic purpura |
| fr | Syndrome de sensibilisation aux érythrocytes | Syndrome de Gardner-Diamond · Syndrome des ecchymoses douloureuses · Purpura psychogène |
| de | Erythrozytenautosensibilisierung | Ekchymosen-Syndrom, schmerzhaftes · GDS · Gardner-Diamond-Syndrom · Psychogene Purpura |
| es | Síndrome de sensibilización autoeritrocitaria | GDS · Púrpura psicógena · Síndrome de Gardner-Diamond · Síndrome de hematoma doloroso |
| it | Sindrome da sensibilizzazione autoeritrocitaria | GDS · Porpora psicogena · Sindrome da ecchimosi dolorose · Sindrome di Gardner-Diamond |
| nl | Auto-erytrocyt sensibiliseringssyndroom | GDS · Gardner-Diamondsyndroom · Pijnlijke blauwe plekken-syndroom · Psychogene onderhuidse bloedingen · Psychogene purpura |
| pt | Síndrome de sensibilização auto-eritrocitária | |
| pl | Zespół autosensytyzacji erytrocytów | GDS · plamica psychogenna · Zespół bolesnych wybroczyn · Zespół Gardnera i Diamonda |
| cs | Syndrom autoerytrocytární senzitizace | GDS · Psychogenní purpura · Gardnerův-Diamondův syndrom · Syndrom bolestivých pohmožděnin · Gardner-Diamondův syndrom |
| uk | Синдром аутоеритроцитарної сенсибілізації | Синдром Гарднера-Даймонда · GDS · Синдром болісних синців · Психогенна пурпура |
| zh | 自体红细胞致敏综合征 | 疼痛性瘀斑综合征 |
| tr | Otoritrosit sensitizasyon sendromu | GDS · Psikojenik purpura · Gardner-Diamond sendromu · Ağrılı morarma sendromu |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | D69.2 | NTBT | attributed | validated |
| ICD-11 | ED02 | E | specific | validated |
| MONDO | 0017943 | E | validated | |
| MeSH | C535645 | E | validated | |
| UMLS | C0301928 | E | validated | |
| GARD | 6481 | E | validated | |
| MedDRA | 10078888 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:315350Autoimmune disease with skin involvement
rare skin diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
2 records| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Cases/families | 170 cases | Worldwide | Case(s) | Validated | 19192020[PMID] | |
| Point prevalence | <1 / 1 000 000 | — | Worldwide | Class only | Validated | ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
42 annotations · validated 2021-05-05| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0000978 | Bruising susceptibility | |
| HP:0031364 | Ecchymosis | |
| Frequent (79-30%) | ||
| HP:0040064 | Abnormality of limbs | |
| HP:0000708 | Atypical behavior | |
| HP:0012531 | Pain | |
| HP:0031190 | Superficial dermal perivascular inflammatory infiltrate | |
| Occasional (29-5%) | ||
| HP:0000271 | Abnormality of the face | |
| HP:0000707 | Abnormality of the nervous system | |
| HP:0000739 | Anxiety | |
| HP:0002829 | Arthralgia | |
| HP:0025406 | Asthenia | |
| HP:0012076 | Borderline personality disorder | |
| HP:0000716 | Depression | |
| HP:0002014 | Diarrhea | |
| HP:0000969 | Edema | |
| HP:0000712 | Emotional lability | |
| HP:0410019 | Epigastric pain | |
| HP:0000421 | Epistaxis | |
| HP:0025474 | Erythematous plaque | |
| HP:0012378 | Fatigue | |
| HP:0001945 | Fever | |
| HP:0002315 | Headache | |
| HP:0000790 | Hematuria | |
| HP:0008352 | Impaired platelet adhesion | |
| HP:0012233 | Intramuscular hematoma | |
| HP:0000132 | Menorrhagia | |
| HP:0003326 | Myalgia | |
| HP:0002018 | Nausea | |
| HP:0008770 | Obsessive-compulsive trait | |
| HP:0030140 | Oral cavity bleeding | |
| HP:0033676 | Posttraumatic stress symptom | |
| HP:0003645 | Prolonged partial thromboplastin time | |
| HP:0000989 | Pruritus | |
| HP:0100716 | Self-injurious behavior | |
| HP:0002321 | Vertigo | |
| HP:0002013 | Vomiting | |
| Very rare (<4-1%) | ||
| HP:0001877 | Abnormal erythrocyte morphology | |
| HP:0001973 | Autoimmune thrombocytopenia | |
| HP:0002239 | Gastrointestinal hemorrhage | |
| HP:0002170 | Intracranial hemorrhage | |
| HP:0005261 | Joint hemorrhage | |
| HP:0001894 | Thrombocytosis | |
Run the differential on the 2 obligate / very frequent terms
Annotation source: 29644197[PMID]_19192020[PMID]_28363337[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/324636
- This record as JSON: /data/d/324636.json