Ethylene glycol poisoning
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- All ages
- Status
- active
A rare poisoning resulting in elevated anion gap metabolic acidosis, due to the production of glycolic acid, glyoxylic acid, and oxalic acid by alcohol dehydrogenase (ADH) in the liver when ethylene glycol is metabolized, characterized initially by euphoria, slurred speech, encephalopathy, coma and seizures, and followed by late manifestations such as tachycardia, arrhythmias, myocardial depression, hemodynamic imbalance and, finally, acute renal failure.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Ethylene glycol poisoning | |
| fr | Intoxication par l'éthylène glycol | |
| de | Ethylenglykol-Vergiftung | |
| es | Intoxicación por etilenglicol | |
| it | Intossicazione da glicole etilenico | |
| nl | Ethyleenglycolvergiftiging | |
| pt | Intoxicação por etilenoglicol | |
| pl | Zatrucie glikolem etylenowym | |
| cs | Otrava ethylenglykolem | |
| uk | Отруєння етиленгліколем | |
| zh | 乙二醇中毒 | |
| tr | Etilen glikol zehirlenmesi |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | T52.3 | NTBT | attributed | validated |
| ICD-11 | NE61 | NTBT | attributed | validated |
| MONDO | 0017861 | E | validated | |
| UMLS | C0413194 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:556508Rare disorder due to poisoning
rare disorders due to toxic effects
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only | Not yet validated | ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
44 annotations · validated 2020-03-02| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0003128 | Lactic acidosis | |
| HP:0001942 | Metabolic acidosis | |
| Frequent (79-30%) | ||
| HP:0001251 | Ataxia | |
| HP:0001289 | Confusion | |
| HP:0002329 | Drowsiness | |
| HP:0031962 | Elevated serum anion gap | |
| HP:0031844 | Euphoria | |
| HP:0002901 | Hypocalcemia | |
| HP:0002018 | Nausea | |
| HP:0001350 | Slurred speech | |
| HP:0001649 | Tachycardia | |
| HP:0002789 | Tachypnea | |
| HP:0002013 | Vomiting | |
| Occasional (29-5%) | ||
| HP:0002793 | Abnormal pattern of respiration | |
| HP:0007695 | Abnormal pupillary light reflex | |
| HP:0030955 | Alcoholism | |
| HP:0005110 | Atrial fibrillation | |
| HP:0001259 | Coma | |
| HP:0001635 | Congestive heart failure | |
| HP:0000961 | Cyanosis | |
| HP:0004885 | Episodic respiratory distress | |
| HP:0005263 | Gastritis | |
| HP:0002315 | Headache | |
| HP:0002153 | Hyperkalemia | |
| HP:0000822 | Hypertension | |
| HP:0002615 | Hypotension | |
| HP:0001657 | Prolonged QT interval | |
| HP:0100598 | Pulmonary edema | |
| HP:0000083 | Renal insufficiency | |
| HP:0031273 | Shock | |
| Very rare (<4-1%) | ||
| HP:0031910 | Abnormal cranial nerve physiology | |
| HP:0002181 | Cerebral edema | |
| HP:0011037 | Decreased urine output | |
| HP:0001298 | Encephalopathy | |
| HP:0010628 | Facial palsy | |
| HP:0030157 | Flank pain | |
| HP:0000790 | Hematuria | |
| HP:0002045 | Hypothermia | |
| HP:0001336 | Myoclonus | |
| HP:0000639 | Nystagmus | |
| HP:0000602 | Ophthalmoplegia | |
| HP:0000124 | Renal tubular dysfunction | |
| HP:0008682 | Renal tubular epithelial necrosis | |
| HP:0001250 | Seizure | |
Run the differential on the 2 obligate / very frequent terms
Annotation source: 26566024[PMID]_29899323[PMID]_24215789[PMID]_22085425[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/31826
- This record as JSON: /data/d/31826.json