Methanol poisoning
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- All ages
- Status
- active
Methanol poisoning is a rare poisoning resulting in elevated anion gap metabolic acidosis, due to the alcohol dehydrogenase (ADH)-mediated production of formic acid (which is poisonous to the central nervous system), and characterized by dizziness, nausea, vomiting, confusion, metabolic acidosis, visual disturbances (which if left untreated can lead to blindness), coma, and death (due to respiratory failure).
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Methanol poisoning | |
| fr | Intoxication par le méthanol | |
| de | Methanol-Vergiftung | |
| es | Intoxicación por metanol | |
| it | Intossicazione da metanolo | |
| nl | Methanolvergiftiging | |
| pt | Intoxicação por metanol | |
| pl | Zatrucie metanolem | |
| cs | Otrava metanolem | |
| uk | Отруєння метанолом | |
| zh | 甲醇中毒 | |
| tr | Metanol zehirlenmesi |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | T51.1 | E | specific | validated |
| ICD-11 | NE61 | NTBT | index | validated |
| MONDO | 0017860 | E | validated | |
| UMLS | C0392621 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:556508Rare disorder due to poisoning
rare disorders due to toxic effects
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only | Not yet validated | ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
29 annotations · validated 2020-03-02| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0001942 | Metabolic acidosis | |
| Frequent (79-30%) | ||
| HP:0031982 | Abnormal putamen morphology | |
| HP:0030955 | Alcoholism | |
| HP:0000622 | Blurred vision | |
| HP:0003077 | Hyperlipidemia | |
| HP:0000822 | Hypertension | |
| HP:0002170 | Intracranial hemorrhage | |
| HP:0000505 | Visual impairment | |
| Occasional (29-5%) | ||
| HP:0002027 | Abdominal pain | |
| HP:0002500 | Abnormal cerebral white matter morphology | |
| HP:0001273 | Abnormal corpus callosum morphology | |
| HP:0002453 | Abnormal globus pallidus morphology | |
| HP:0000587 | Abnormal optic nerve morphology | |
| HP:0012128 | Basal ganglia necrosis | |
| HP:0007146 | Bilateral basal ganglia lesions | |
| HP:0000618 | Blindness | |
| HP:0001259 | Coma | |
| HP:0001289 | Confusion | |
| HP:0002014 | Diarrhea | |
| HP:0001658 | Myocardial infarction | |
| HP:0005978 | Type II diabetes mellitus | |
| HP:0002013 | Vomiting | |
| Very rare (<4-1%) | ||
| HP:0002339 | Abnormal caudate nucleus morphology | |
| HP:0031422 | Abnormal morphology of the cerebellar cortex | |
| HP:0001342 | Cerebral hemorrhage | |
| HP:0005291 | Inflammatory arteriopathy | |
| HP:0004754 | Permanent atrial fibrillation | |
| HP:0001250 | Seizure | |
| HP:0100651 | Type I diabetes mellitus | |
Run the differential on the 1 obligate / very frequent terms
Annotation source: 20139536[PMID]_29171574[PMID]_26806851[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/31825
- This record as JSON: /data/d/31825.json