Acute erythroid leukemia
Synonyms: AML M6 · Acute myeloid leukemia M6 · Erythroleukemia
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- Adolescent, Adult, Childhood, Elderly
- Status
- active
A rare unclassified acute myeloid leukemia characterized by a proliferation of immature cells exclusively of the erythroid lineage without a significant myeloblastic component. Microscopically, the cells may be undifferentiated or proerythroblastic in appearance. Patients may present with pancytopenia with fatigue, infections, and mucocutaneous bleedings, as well as weight loss, fever, and night sweats. Prognosis is poor.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Acute erythroid leukemia | AML M6 · Acute myeloid leukemia M6 · Erythroleukemia |
| fr | Leucémie érythroblastique | Erythroleucémie · LAM M6 · Leucémie aiguë myéloïde M6 |
| de | Akute Erythroleukämie | AML-M6 · Erythroleukämie · Leukämie, akute myeloische, Typ 6 |
| es | Leucemia eritroide aguda | Eritroleucemia · Leucemia mieloblástica aguda tipo 6 · MLA-M6 |
| it | Leucemia eritroide acuta | AML-M6 · Eritroleucemia · Leucemia mieloblastica acuta, tipo 6 |
| nl | Acute erytroïde leukemie | AML-M6 · Acute myeloblastische leukemie type 6 · Erytroleukemie |
| pt | Leucemia eritroblástica aguda | Leucemia mieloblástica aguda tipo 6 |
| pl | Ostra erytroleukemia | AML-M6 · Erytroleukemia · Ostra białaczka mieloblastyczna typu 6 |
| cs | Akutní erytroidní leukémie | AML M6 · Akutní myeloidní leukémie M6 · Erytroleukémie |
| uk | Гострий еритроїдний лейкоз | Гостра мієлоїдна лейкемія M6 · AML M6 · Еритролейкоз |
| zh | 急性红白血病 | 急性髓系白血病M6 |
| tr | Akut eritroid lösemi | AML M6 · Eritrolösemi · Akut miyeloid lösemi M6 |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| OMIM | 133180 | BTNT | validated | |
| ICD-10 | C94.0 | NTBT | attributed | validated |
| ICD-11 | 2A60.35 | E | specific | validated |
| MONDO | 0017858 | E | validated | |
| MeSH | D004915 | E | validated | |
| UMLS | C0023440 | E | validated | |
| GARD | 9620 | E | validated | |
| MedDRA | 10000739 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:167714Unclassified acute myeloid leukemia
rare hematological diseases; rare neoplastic diseases; rare transplant-related disorders
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
2 records| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Annual incidence | Unknown | — | Worldwide | Class only | Validated | WHO Classification of Tumours[OTHER] |
| Point prevalence | Unknown | — | Worldwide | Class only | Validated | WHO Classification of Tumours[OTHER] |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
9 annotations · validated 2019-05-03| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Frequent (79-30%) | ||
| HP:0025035 | Abnormal proerythroblast morphology | |
| HP:0001903 | Anemia | |
| HP:0031020 | Bone marrow hypercellularity | |
| HP:0012133 | Erythroid hypoplasia | |
| HP:0001882 | Leukopenia | |
| HP:0005508 | Monoclonal immunoglobulin M proteinemia | |
| HP:0001876 | Pancytopenia | |
| HP:0004828 | Refractory anemia with ringed sideroblasts | |
| Occasional (29-5%) | ||
| HP:0005528 | Bone marrow hypocellularity | |
Annotation source: 28006859[PMID]_6589033[PMID]_3471269[PMID]_6948132[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/318
- This record as JSON: /data/d/318.json