Cyanide-induced parkinsonism-dystonia
- Type
- Disease
- Group
- Disorder
- Age of onset
- All ages
- Status
- active
A rare parkinsonian syndrome due to intoxication which develops in individuals surviving an acute cyanide intoxication episode or due to chronic exposure to small cyanide doses. It presents several weeks after acute exposure with progressive typical clinical features of parkinsonism including bradykinesia, rigidity, dystonia, hypomimia, hypokinetic dysarthria, postural instability and retropulsion but no resting or postural tremor. Brain MRI reveals bilateral lesions in the pallidum, posterior putamen, substantia nigra, subthalamic nucleus, temporal and occipital cortex, and cerebellum.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Cyanide-induced parkinsonism-dystonia | |
| fr | Parkinsonisme-dystonie par intoxication au cyanure | |
| de | Zyanid-induzierter Parkinsonismus | |
| es | Distonía-parkinsonismo inducido por cianuro | |
| it | Parkinsonismo da cianuro | |
| nl | Parkinsonisme-dystonie geïnduceerd door cyanide | |
| pt | Parkinson induzido pelo cianeto | |
| pl | Parkinsonizm indukowany cyjankiem | |
| cs | Parkinsonismus indukovaný kyanidem | |
| uk | Паркінсонізм-дистонія, спричинена ціанідами | |
| zh | 氰化物引起的帕金森综合症-肌张力障碍 | |
| tr | Siyanür kaynaklı parkinsonizm-distoni |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | G21.2 | NTBT | attributed | validated |
| ICD-11 | 8A00.2Y | NTBT | index | validated |
| MONDO | 0017640 | E | validated | |
| MONDO | 17640 | E | validated | |
| UMLS | C4707859 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (2):
- ORPHA:556508Rare disorder due to poisoning
rare disorders due to toxic effects - ORPHA:306679Rare parkinsonian syndrome due to intoxication
rare neurological diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
0 recordsNo prevalence record in this release.
HPO phenotypes
20 annotations · validated 2018-03-30| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Frequent (79-30%) | ||
| HP:0011121 | Abnormal skin morphology | |
| HP:0002167 | Abnormality of speech or vocalization | |
| HP:0002425 | Anarthria | |
| HP:0000741 | Apathy | |
| HP:0002067 | Bradykinesia | |
| HP:0002120 | Cerebral cortical atrophy | |
| HP:0004673 | Decreased facial expression | |
| HP:0001260 | Dysarthria | |
| HP:0002987 | Elbow flexion contracture | |
| HP:0002527 | Falls | |
| HP:0007034 | Generalized hyperreflexia | |
| HP:0007975 | Hypometric horizontal saccades | |
| HP:0000298 | Mask-like facies | |
| HP:0001300 | Parkinsonism | |
| HP:0002172 | Postural instability | |
| HP:0002322 | Resting tremor | |
| HP:0002063 | Rigidity | |
| HP:0007311 | Short stepped shuffling gait | |
| HP:0002362 | Shuffling gait | |
| HP:0012157 | Subcortical cerebral atrophy | |
Annotation source: 2733710[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/306692
- This record as JSON: /data/d/306692.json