Manganese poisoning
Synonyms: Manganese intoxication · Manganism
- Type
- Disease
- Group
- Disorder
- Age of onset
- All ages
- Status
- active
A rare disorder due to toxic effects characterized by a progressive, permanent affliction of the extrapyramidal system with the globus pallidus and striatum as primary targets of neurotoxic effects. Symptoms include headache, insomnia, memory loss, emotional instability, hyperreflexia, dystonia, tremor, speech disturbances, and gait abnormalities. Individual factors like age, gender, genetics, and pre-existing medical conditions appear to have a profound impact on manganese toxicity.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Manganese poisoning | Manganese intoxication · Manganism |
| fr | Intoxication au manganèse | Manganisme |
| de | Mangan-Vergiftung | |
| es | Intoxicación por manganeso | Manganismo |
| it | Avvelenamento da manganese | Intossicazione da manganese · Manganismo |
| nl | Mangaanvergiftiging | Mangaanintoxicatie · Manganisme |
| pt | Intoxicação por manganésio | |
| pl | Zatrucie manganem | Intoksykacja manganem · Manganizm |
| cs | Otrava manganem | Intoxikace manganem · Manganismus |
| uk | Отруєння марганцем | Марганцева інтоксикація · Манганізм |
| zh | 锰中毒 | 锰中毒 |
| tr | Manganez zehirlenmesi | Manganizm · Manganez intoksikasyonu |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | T57.2 | E | specific | validated |
| ICD-11 | NE61 | NTBT | index | validated |
| MONDO | 0017638 | E | validated | |
| MeSH | D020149 | E | validated | |
| UMLS | C0677050 | E | validated | |
| MedDRA | 10058951 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (2):
- ORPHA:556508Rare disorder due to poisoning
rare disorders due to toxic effects - ORPHA:306679Rare parkinsonian syndrome due to intoxication
rare neurological diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
0 recordsNo prevalence record in this release.
HPO phenotypes
30 annotations · validated 2018-03-30| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0002453 | Abnormal globus pallidus morphology | |
| HP:0002071 | Abnormality of extrapyramidal motor function | |
| HP:0003287 | Abnormality of mitochondrial metabolism | |
| HP:0002067 | Bradykinesia | |
| HP:0002396 | Cogwheel rigidity | |
| HP:0001332 | Dystonia | |
| HP:0000712 | Emotional lability | |
| HP:0001288 | Gait disturbance | |
| HP:0002315 | Headache | |
| HP:0001276 | Hypertonia | |
| HP:0025464 | Increased reactive oxygen species production | |
| HP:0002354 | Memory impairment | |
| HP:0002172 | Postural instability | |
| HP:0002174 | Postural tremor | |
| HP:0006979 | Sleep-wake cycle disturbance | |
| Frequent (79-30%) | ||
| HP:0000718 | Aggressive behavior | |
| HP:0002304 | Akinesia | |
| HP:0000722 | Compulsive behaviors | |
| HP:0001289 | Confusion | |
| HP:0030018 | Decreased female libido | |
| HP:0040306 | Decreased male libido | |
| HP:0000746 | Delusion | |
| HP:0000802 | Impotence | |
| HP:0000748 | Inappropriate laughter | |
| HP:0000505 | Visual impairment | |
| Occasional (29-5%) | ||
| HP:5200321 | Amplification of sexual behavior | |
| HP:0000716 | Depression | |
| HP:0000738 | Hallucinations | |
| HP:0031466 | Impairment in personality functioning | |
| HP:0000737 | Irritability | |
Run the differential on the 12 obligate / very frequent terms
Annotation source: 26154659[PMID]_7936278[PMID]_5101169[PMID]_26154659[PMID]_20403794[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/306682
- This record as JSON: /data/d/306682.json