Tick-borne encephalitis
Synonyms: TBE
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- All ages
- Status
- active
An infectious disease characterized by central nervous system (CNS) involvement caused by the TBE virus (TBEV) and transmitted to humans principally by the bite of ticks from the <i>Ixodes</i> genus. The symptomatology is often biphasic, with the initial phase being associated with a nonspecific febrile illness and the second phase with meningitis, meningoencephalitis or meningoencephalomyelitis.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Tick-borne encephalitis | TBE |
| fr | Encéphalite à tiques | = en |
| de | Zeckenenzephalitis | Lymphadenopathie, zeckenstichassoziierte · TBE |
| es | Encefalitis transmitida por garrapatas | ETG |
| it | Encefalite trasmessa da zecche | |
| nl | Tekenencefalitis | = en |
| pt | Encefalite por picada de carraça | = en |
| pl | Kleszczowe zapalenie mózgu | = en |
| cs | Klíšťová encefalitida | = en |
| uk | Кліщовий енцефаліт | = en |
| zh | 蜱传脑炎 | = en |
| tr | Keneyle geçen ensefalit | = en |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | A84.0 | BTNT | specific | validated |
| ICD-10 | A84.1 | BTNT | specific | validated |
| ICD-10 | A84.8 | BTNT | specific | validated |
| ICD-10 | A84.9 | BTNT | specific | validated |
| ICD-11 | 1C80 | NTBT | index | validated |
| MONDO | 0017572 | E | validated | |
| MeSH | D004675 | E | validated | |
| UMLS | C0014061 | E | validated | |
| GARD | 5216 | E | validated | |
| MedDRA | 10043847 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (2):
- ORPHA:166490Infectious disease with epilepsy
rare neurological diseases - ORPHA:98252Infectious encephalitis
rare neurological diseases; rare infectious diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only | Not yet validated | ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
63 annotations · validated 2020-04-10| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0012229 | CSF pleocytosis | |
| Frequent (79-30%) | ||
| HP:0011112 | Abnormality of serum cytokine level | |
| HP:0002039 | Anorexia | |
| HP:0002829 | Arthralgia | |
| HP:0012378 | Fatigue | |
| HP:0002315 | Headache | |
| HP:0001882 | Leukopenia | |
| HP:0003326 | Myalgia | |
| HP:0002018 | Nausea | |
| HP:0020071 | Viremia | |
| Occasional (29-5%) | ||
| HP:0012332 | Abnormal autonomic nervous system physiology | |
| HP:0001291 | Abnormal cranial nerve morphology | |
| HP:3000047 | Abnormal glossopharyngeal nerve morphology | |
| HP:0011392 | Abnormality of the vestibular nerve | |
| HP:0000708 | Atypical behavior | |
| HP:0003418 | Back pain | |
| HP:0100543 | Cognitive impairment | |
| HP:0032044 | Decreased vigilance | |
| HP:0000716 | Depression | |
| HP:0031987 | Diminished ability to concentrate | |
| HP:0002015 | Dysphagia | |
| HP:0011227 | Elevated circulating C-reactive protein concentration | |
| HP:0003565 | Elevated erythrocyte sedimentation rate | |
| HP:0001262 | Excessive daytime somnolence | |
| HP:0000365 | Hearing impairment | |
| HP:0002487 | Hyperkinetic movements | |
| HP:0002311 | Incoordination | |
| HP:0003237 | Increased circulating IgG level | |
| HP:0003496 | Increased circulating IgM level | |
| HP:0001974 | Increased total leukocyte count | |
| HP:0009763 | Limb pain | |
| HP:0001287 | Meningitis | |
| HP:0000602 | Ophthalmoplegia | |
| HP:0003470 | Paralysis | |
| HP:0000751 | Personality changes | |
| HP:0000613 | Photophobia | |
| HP:0004372 | Reduced consciousness | |
| HP:0003202 | Skeletal muscle atrophy | |
| HP:0002360 | Sleep abnormality | |
| HP:0003474 | Somatic sensory dysfunction | |
| HP:0011098 | Speech apraxia | |
| HP:0025258 | Stiff neck | |
| HP:0001873 | Thrombocytopenia | |
| HP:0000360 | Tinnitus | |
| HP:0001308 | Tongue fasciculations | |
| HP:0001337 | Tremor | |
| HP:0011450 | Unusual CNS infection | |
| HP:0002321 | Vertigo | |
| HP:0000505 | Visual impairment | |
| HP:0002013 | Vomiting | |
| Very rare (<4-1%) | ||
| HP:0012747 | Abnormal brainstem MRI signal intensity | |
| HP:0001637 | Abnormal myocardium morphology | |
| HP:0011441 | Abnormality of the medulla oblongata | |
| HP:0001259 | Coma | |
| HP:0031258 | Delirium | |
| HP:0002910 | Elevated circulating hepatic transaminase concentration | |
| HP:0010628 | Facial palsy | |
| HP:0030196 | Fatigable weakness of respiratory muscles | |
| HP:0007359 | Focal-onset seizure | |
| HP:0002197 | Generalized-onset seizure | |
| HP:0012486 | Myelitis | |
| HP:0031003 | Polyneuritis | |
| HP:0000709 | Psychosis | |
Run the differential on the 1 obligate / very frequent terms
Annotation source: 25984517[PMID]_28928417[PMID]_26601448[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/297
- This record as JSON: /data/d/297.json