ORPHA:2965
Prolactinoma
Synonyms: Lactotroph adenoma · PRL-secreting pituitary adenoma · PRLoma · Pituitary lactotrophic adenoma · Prolactin-secreting pituitary adenoma
- Type
- Disease
- Group
- Disorder
- Inheritance
- Autosomal dominant
- Age of onset
- Adolescent, Adult, Childhood, Elderly
- Status
- active
A rare, usually benign, neoplasm of the anterior pituitary gland that results in hyperprolactinemia. The most common clinical manifestations are amenorrhea and infertility in women; and impotence, decreased libido and infertility in men.
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Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Prolactinoma | Lactotroph adenoma · PRL-secreting pituitary adenoma · PRLoma · Pituitary lactotrophic adenoma · Prolactin-secreting pituitary adenoma |
| fr | Prolactinome | Adénome hypophysaire à PRL · Adénome hypophysaire à prolactine · Adénome lactotrope · Adénome lactotrope hypophysaire · PRLome |
| de | Prolaktinom | LTH-produzierendes Hypophysen-Adenom · Laktotropes Adenom der Hypophyse · PRLom · Prolaktin-produzierendes Hypophysen-Adenom |
| es | Prolactinoma | Adenoma hipofisario secretor de PRL · Adenoma hipofisario secretor de prolactina · Adenoma lactotrofo · Adenoma lactotrófico hipofisario · PRLoma |
| it | Prolattinoma | Adenoma ipofisario PRL-secernente · Adenoma ipofisario secernente prolattina · Adenoma lattotropo · Adenoma lattotropo ipofisario · PRLoma |
| nl | Prolactinoom | Lactotroof hypofyseadenoom · Lactotroop adenoom · PRL-secreterend hypofyseadenoom · PRLoom · Prolactinesecreterend hypofyseadenoom |
| pt | Prolactinoma | Adenoma hipofisário lactotrófico · Adenoma hipofisário secretor de PRL · Adenoma lactotrófico · Adenoma secretor de prolactina · PRLoma |
| pl | Prolaktinoma | Gruczolak laktotropowy · Gruczolak laktotropowy przysadki · Gruczolak przysadki wydzielając prolaktynę · Gruczolak przysadki wydzielający PRL · PRLoma |
| cs | Prolaktinom | Laktotropní adenom · Adenom hypofýzy produkující PRL · PRLom · Laktotropní adenom hypofýzy · Adenom hypofýzy produkující prolaktin |
| uk | Пролактинома | Лактотрофна аденома · Лактотрофна аденома гіпофіза · PRLoma · PRL-секретуюча аденома гіпофіза · Пролактин-секретуюча аденома гіпофіза |
| zh | 催乳素瘤 | 分泌催乳素的垂体腺瘤 |
| tr | Prolaktinom | PRLoma · Laktotrof adenom · Hipofiz laktotrofik adenom · PRL-salgılayıcı hipofiz adenomu · Prolaktin-salgılayıcı hipofiz adenomu |
Definition in:
2
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | D35.2 | ND | attributed | validated |
| ICD-11 | 2F37.Y | NTBT | index | validated |
| ICD-11 | XH1QS0 | E | specific | validated |
| MONDO | 0010911 | E | validated | |
| MeSH | D015175 | E | validated | |
| UMLS | C0033375 | E | validated | |
| GARD | 4508 | E | validated | |
| MedDRA | 10036832 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
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Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (4):
- ORPHA:314753Functioning pituitary adenoma
rare endocrine diseases; rare neoplastic diseases - ORPHA:715120Hyperpituitarism
rare endocrine diseases - ORPHA:399831Rare female infertility due to hypothalamic-pituitary-gonadal axis disorder
rare infertility disorders - ORPHA:399572Rare male infertility due to hypothalamic-pituitary-gonadal axis disorder
rare infertility disorders
No children.
Codes that Orphanet moved or referred to this one:
- ORPHA:98311OBSOLETE: Male infertility with impaired virilization due to a hypothalamic and pituitary disorder associated with hyperprolactinemia referred to · inactive
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Genes
3 direct| Gene | Association | Status | HGNC | Ensembl | OMIM | Locus | Name | Source of validation |
|---|---|---|---|---|---|---|---|---|
| AIP | Major susceptibility factor in | Assessed | HGNC:358 | ENSG00000110711 | 605555 | 11q13.2 | AHR interacting HSP90 co-chaperone | 22319033[PMID]_23321498[PMID] |
| CDH23 | Major susceptibility factor in | Assessed | HGNC:13733 | ENSG00000107736 | 605516 | 10q22.1 | cadherin related 23 | 28413019[PMID] |
| MEN1 | Major susceptibility factor in | Assessed | HGNC:7010 | ENSG00000133895 | 613733 | 11q13.1 | menin 1 | 23321498[PMID] |
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Prevalence and incidence
5 records| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | 1-5 / 10 000 | 44.4 / 100 000 | United Kingdom | Value and class | Validated | 19650784[PMID] |
| Point prevalence | 6-9 / 10 000 | 62 / 100 000 | Belgium | Value and class | Validated | 16968795[PMID] |
| Point prevalence | 1-5 / 10 000 | 45.7 / 100 000 | Switzerland | Value and class | Validated | 19968031[PMID] |
| Annual incidence | 1-9 / 100 000 | 2.05 / 100 000 | Malta | Value and class | Validated | 23239049[PMID] |
| Point prevalence | 1-5 / 10 000 | 50.7 / 100 000 | Europe | Value and class | Validated | 16968795[PMID]_ 19650784[PMID]_ 19968031[PMID]_ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
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HPO phenotypes
50 annotations · validated 2016-01-25| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0000140 | Abnormality of the menstrual cycle | |
| HP:0012503 | Abnormality of the pituitary gland | |
| HP:0000141 | Amenorrhea | |
| HP:0030018 | Decreased female libido | |
| HP:0000868 | Decreased fertility in females | |
| HP:0012041 | Decreased fertility in males | |
| HP:0100639 | Erectile dysfunction | |
| HP:0000134 | Female hypogonadism | |
| HP:0100829 | Galactorrhea | |
| HP:0000135 | Hypogonadism | |
| HP:0000044 | Hypogonadotropic hypogonadism | |
| HP:0000802 | Impotence | |
| HP:0000858 | Irregular menstruation | |
| HP:0000026 | Male hypogonadism | |
| Frequent (79-30%) | ||
| HP:0011362 | Abnormal hair quantity | |
| HP:0011748 | Adrenocorticotropic hormone deficiency | |
| HP:0011735 | Adrenocorticotropin deficient adrenal insufficiency | |
| HP:0011734 | Central adrenal insufficiency | |
| HP:0002920 | Decreased circulating ACTH level | |
| HP:0030016 | Dyspareunia | |
| HP:0003388 | Easy fatigability | |
| HP:0012378 | Fatigue | |
| HP:0000771 | Gynecomastia | |
| HP:0002315 | Headache | |
| HP:0002615 | Hypotension | |
| HP:0002017 | Nausea and vomiting | |
| HP:0000938 | Osteopenia | |
| HP:0000939 | Osteoporosis | |
| HP:0000980 | Pallor | |
| HP:0008245 | Pituitary hypothyroidism | |
| HP:0000529 | Progressive visual loss | |
| HP:0008240 | Secondary growth hormone deficiency | |
| HP:0002013 | Vomiting | |
| Occasional (29-5%) | ||
| HP:0006897 | Abducens palsy | |
| HP:0000830 | Anterior hypopituitarism | |
| HP:0030521 | Bitemporal hemianopia | |
| HP:0000618 | Blindness | |
| HP:0006824 | Cranial nerve paralysis | |
| HP:0000823 | Delayed puberty | |
| HP:0000651 | Diplopia | |
| HP:0000845 | Elevated circulating growth hormone concentration | |
| HP:0007011 | Fourth cranial nerve palsy | |
| HP:0012377 | Hemianopia | |
| HP:0030517 | Heteronymous hemianopia | |
| HP:0007942 | Internal ophthalmoplegia | |
| HP:0012246 | Oculomotor nerve palsy | |
| HP:0000508 | Ptosis | |
| HP:0001250 | Seizure | |
| HP:0001117 | Sudden loss of visual acuity | |
| HP:0002321 | Vertigo | |
Run the differential on the 12 obligate / very frequent terms
Annotation source: 21296991[PMID]_25208537[PMID]_26641246[PMID]_24195502[PMID]_22542456[PMID]_25532043[PMID]_23321498[PMID]_22319033[PMID]_21753072[PMID]_17993773[PMID]_19407509[PMID]_22720333[PMID]
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Sources for this card
- Orphanet page: orpha.net/en/disease/detail/2965
- This record as JSON: /data/d/2965.json