Fixed drug eruption
- Type
- Disease
- Group
- Disorder
- Inheritance
- Not applicable
- Age of onset
- All ages
- Status
- active
A rare hypersensitivity reaction characterized by the appearance of erythematous or violaceous, round, sometimes painful, plaques that may or may not result in long-lasting pigmentation and which recur (usually at the same site) upon re-exposure to the causative medication. The severe form of the disease, generalized bullous fixed drug eruption, occurs typically in the elderly and may be life-threatening. Onset usually occurs 30 minutes to several hours after administration of the causal medication. Many medications, including paracetamol, have been implicated. The disease may rarely be induced by food. Histology is characterized by interface dermatitis or epidermal necrolysis in bullous forms.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Fixed drug eruption | |
| fr | Erythème pigmenté fixe | |
| de | Fixes Arzneimittelexanthem | |
| es | Erupción fija por fármacos | Erupción fija medicamentosa |
| it | Eruzione fissa da farmaci | |
| nl | Gefixeerde geneesmiddeleneruptie | |
| pt | Eritema pigmentado fixo | |
| pl | Rumień barwnikowy trwały | |
| cs | Fixovaný pigmentovaný erytém | |
| uk | Фіксований висип, викликаний ліками | |
| zh | 固定性药疹 | |
| tr | Sabit ilaç püskürmesi |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | L25.1 | NTBT | attributed | validated |
| ICD-11 | EH66 | E | specific | validated |
| MONDO | 0017395 | E | validated | |
| MONDO | 17395 | E | validated | |
| UMLS | C0221242 | E | validated | |
| MedDRA | 10016740 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:293815Toxic dermatosis
rare skin diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
1 record| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Point prevalence | Unknown | — | Worldwide | Class only | Validated | ORPHANET_26548517[PMID] |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
18 annotations · validated 2021-05-04| HPO | Term (as annotated by Orphanet) | Diagnostic |
|---|---|---|
| Very frequent (99-80%) | ||
| HP:0020172 | Adverse drug response | |
| HP:0410323 | Drug allergy | |
| HP:0010783 | Erythema | |
| Frequent (79-30%) | ||
| HP:0025474 | Erythematous plaque | |
| HP:0003341 | Junctional split | |
| HP:0011356 | Regional abnormality of skin | |
| Occasional (29-5%) | ||
| HP:0008066 | Abnormal blistering of the skin | |
| HP:0012378 | Fatigue | |
| HP:0001945 | Fever | |
| HP:0000953 | Hyperpigmentation of the skin | |
| HP:0000155 | Oral ulcer | |
| HP:0032156 | Skin detachment | |
| HP:0200041 | Skin erosion | |
| HP:0010280 | Stomatitis | |
| Very rare (<4-1%) | ||
| HP:0025143 | Chills | |
| HP:0007473 | Crusting erythematous dermatitis | |
| HP:0011354 | Generalized abnormality of skin | |
| HP:0032565 | Vaginal mucosal ulceration | |
Run the differential on the 3 obligate / very frequent terms
Annotation source: 32002848[PMID]_29469697[PMID]_31006486[PMID]
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/293812
- This record as JSON: /data/d/293812.json