Hemolytic disease of the newborn with Kell alloimmunization
Synonyms: Anti-K HDN · Maternal anti-Kell alloimmunization
- Type
- Disease
- Group
- Disorder
- Age of onset
- Infancy, Neonatal
- Status
- active
A rare hematologic disease characterized by the transfer of maternal alloantibodies against red blood cell antigens of the Kell family to a fetus positive for this antigen across the placental barrier, causing suppression of erythropoiesis with reticulocytopenia and anemia, as well as alloimmune hemolysis. Severe anemia may lead to hydrops fetalis. Significant hyperbilirubinemia is rare in this condition.
Names in Orphadata languages
12 of 12 languages| Lang | Name | Synonyms |
|---|---|---|
| en | Hemolytic disease of the newborn with Kell alloimmunization | Anti-K HDN · Maternal anti-Kell alloimmunization |
| fr | Maladie hémolytique du nouveau-né avec allo-immunisation Kell | Allo-immunisation foetomaternelle anti-Kell |
| de | Hämolytische Krankheit des Neugeborenen mit Kell-Alloimmunisierung | Anti-Kell HDN · Anti-Kell-Alloimmunisierung, maternale |
| es | Enfermedad hemolítica neonatal con aloinmunización Kell | Aloinmunización anti-Kell materna · Anti-K HDN |
| it | Malattia emolitica del neonato con alloimmunizzazione di Kell | Alloimmunizzazione materna anti-Kell |
| nl | Hemolytische ziekte van de neonaat met Kell allo-immunisatie | Anti-K HDN · Maternale anti-Kell allo-immunisatie |
| pt | Doença hemolítica do recém-nascido com aloimunização Kell | |
| pl | Choroba hemolityczna u noworodka z alloimmunizacją Kell | Matczyna alloimmunizacja anty-Kell |
| cs | Hemolytická nemoc novorozence s Kell aloimunizací | Kell aloimunizace matky |
| uk | Гемолітична хвороба новонароджених з алоімунізацією Келла | Anti-K HDN · Материнська алоімунізація проти Келл |
| zh | Kell同种异体免疫所致新生儿溶血病 | 母体抗Kell同种异体免疫 |
| tr | Kell alloimmünizasyon ile seyreden yenidoğanın hemolitik hastalığı | Anti-K HDN · Maternal anti-Kell alloimmünizasyon |
Definition in:
Cross-references
qualifier = Orphanet mapping relation| Source | Code | Qualifier | ICD relation | Validation |
|---|---|---|---|---|
| ICD-10 | P55.8 | NTBT | attributed | validated |
| ICD-11 | KA84.1 | NTBT | attributed | validated |
| MONDO | 0017164 | E | validated | |
| UMLS | C0472751 | E | validated |
E exact · NTBT this ORPHAcode is narrower than the target · BTNT broader than the target · ND not decided.
Classification
Preferential parent (Orphanet linearisation):
Parents in the classifications (1):
- ORPHA:275938Hemolytic disease due to fetomaternal alloimmunization
rare hematological diseases
No children.
Genes
0 directOrphanet records no gene directly on this code.
Prevalence and incidence
2 records| Type | Class | Value | Area | Qualification | Validation | Source |
|---|---|---|---|---|---|---|
| Annual incidence | >1 / 1000 | 116 / 100 000 | United Kingdom | Value and class | Validated | 2081378[PMID] |
| Point prevalence | Unknown | — | Worldwide | Class only | Not yet validated | ORPHANET |
Value is Orphadata's ValMoy: the mean estimate per 100 000 for prevalence and incidence, the number of cases or families for case reports.
HPO phenotypes
Orphanet has no HPO annotation for this code in this release.
Sources for this card
- Orphanet page: orpha.net/en/disease/detail/275944
- This record as JSON: /data/d/275944.json